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S4069

SL327

≥98% (HPLC), Mixture of E & Z isomers, solid

Synonym(s):

α-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile, SL 327, SL-327

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About This Item

Empirical Formula (Hill Notation):
C16H12F3N3S
CAS Number:
305350-87-2
Molecular Weight:
335.35
NACRES:
NA.77
PubChem Substance ID:
329824537
UNSPSC Code:
12352200
MDL number:
MFCD06411432
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated, protect from light
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Quality Segment

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated, protect from light

color

white to off-white

mp

127-128.2 °C

solubility

DMSO: >10 mg/mL, H2O: insoluble

storage temp.

2-8°C

SMILES string

N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F

InChI

1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+

InChI key

JLOXTZFYJNCPIS-FYWRMAATSA-N

Application

SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats. It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.
SL327 has been used as an inhibitor of dual specificity mitogen-activated protein kinase (MEK) in Zebrafish embryos and lymphatic endothelial cell (LEC).

Biochem/physiol Actions

SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro.
SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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