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Merck
CN

S4451

Sal003

≥98% (HPLC)

Synonym(s):

(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide, 3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

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About This Item

Empirical Formula (Hill Notation):
C18H15Cl4N3OS
CAS Number:
1164470-53-4
Molecular Weight:
463.21
NACRES:
NA.77
PubChem Substance ID:
329824543
UNSPSC Code:
12352200
MDL number:
MFCD00361095

Key Documents

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InChI key

TVNBASWNLOIQML-IZZDOVSWSA-N

SMILES string

Clc1ccc(NC(=S)NC(NC(=O)\C=C\c2ccccc2)C(Cl)(Cl)Cl)cc1

InChI

1S/C18H15Cl4N3OS/c19-13-7-9-14(10-8-13)23-17(27)25-16(18(20,21)22)24-15(26)11-6-12-4-2-1-3-5-12/h1-11,16H,(H,24,26)(H2,23,25,27)/b11-6+

assay

≥98% (HPLC)

form

powder

storage condition

desiccated, protect from light

color

white to off-white

solubility

DMSO: ≥10 mg/mL

compatibility

for use with Bio-Rad CFX96

storage temp.

2-8°C

Quality Level

100

Related Categories

Application

Sal003 was used to study the role of eIF2α in Subtilase cytotoxin-induced apoptosis in HeLa cells.

Biochem/physiol Actions

Sal003 inhibits the late long-term potentiation (L-LTP) and long-term memory formation in mammalian hippocampal slices. The effect of Sal003 on L-LTP is mediated by the transcription factor, ATF4.
Sal003 is a potent and cell-permeable eIF-2a phosphatase inhibitor.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000337748
0000337748
0000175579
0000175579
119K4624V

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Mauro Costa-Mattioli et al.
Neuron, 61(1), 10-26 (2009-01-17)
Long-lasting forms of synaptic plasticity and memory are dependent on new protein synthesis. Recent advances obtained from genetic, physiological, pharmacological, and biochemical studies provide strong evidence that translational control plays a key role in regulating long-term changes in neural circuits
Charles A Hoeffer et al.
Neuron, 54(2), 186-189 (2007-04-20)
A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. present data from a pharmacogenetic study that places a
Raquel Amorim et al.
PLoS neglected tropical diseases, 11(7), e0005775-e0005775 (2017-07-18)
Zika virus (ZIKV), a member of the Flaviviridae family, is the most recent emerging arbovirus with pandemic potential. During infection, viruses trigger the host cell stress response, leading to changes in RNA translation and the assembly of large aggregates of
Philippos Peidis et al.
Aging, 2(10), 669-677 (2010-11-16)
Histone deacetylase inhibitors (HDACi) comprise a family of chemotherapeutic agents used in the clinic to treat cutaneous T-cell lymphoma and tested for the therapy of other malignancies. Previous reports have shown that eIF2α phosphorylation is induced upon treatment with HDACi.
Katherine R Cronin et al.
PloS one, 7(7), e40994-e40994 (2012-08-01)
Constitutive production of blood coagulation proteins by hepatocytes is necessary for hemostasis. Stressful conditions trigger adaptive cellular responses and delay processing of most proteins, potentially affecting plasma levels of proteins secreted exclusively by hepatocytes. We examined the effect of glucose
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