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Merck
CN

S4760

Sigma-Aldrich

N-Succinyl-Ala-Ala-Ala-p-nitroanilide

elastase substrate, chromogenic, ≥98% (HPLC), powder

Synonym(s):

N-Succinyl-L-alanyl-L-alanyl-L-alanine 4-nitroanilide, N-Succinyl-tri-L-alanine 4-nitroanilide

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About This Item

Empirical Formula (Hill Notation):
C19H25N5O8
CAS Number:
52299-14-6
Molecular Weight:
451.43
Beilstein:
2928351
EC Number:
257-823-5
MDL number:
MFCD00036774
UNSPSC Code:
12352204
PubChem Substance ID:
24899617
NACRES:
NA.32

Key Documents

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Product Name

N-Succinyl-Ala-Ala-Ala-p-nitroanilide, elastase substrate

Quality Level

200

Assay

≥98% (HPLC)

form

powder

solubility

DMF: 25 mg/mL, clear, colorless to light yellow

storage temp.

2-8°C

SMILES string

C[C@H](NC(=O)CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI

1S/C19H25N5O8/c1-10(20-15(25)8-9-16(26)27)17(28)21-11(2)18(29)22-12(3)19(30)23-13-4-6-14(7-5-13)24(31)32/h4-7,10-12H,8-9H2,1-3H3,(H,20,25)(H,21,28)(H,22,29)(H,23,30)(H,26,27)/t10-,11-,12-/m0/s1

InChI key

GVUGADOWXGKRAE-SRVKXCTJSA-N

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General description

N-Succinyl-Ala-Ala-Ala-p-nitroanilide is a chromogenic substrate for chymotrypsin-like serine protease, pancreatic elastase and serine endopeptidase.
Elastase substrate.

Application

N-Succinyl-Ala-Ala-Ala-p-nitroanilide has been used as a substrate
  • for screening elastase activity in lyophilized earthworm fibrinolytic enzymes
  • for quantifying elastase activity in sheep milk
  • in screening honeybee inhibitors in serine protease inhibition assay

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
0000492619
0000492607
0000492607
0000492619
0000469454

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T Fera et al.
The American review of respiratory disease, 133(4), 568-573 (1986-04-01)
In order to determine the acute effect of smoking on elastase in bronchoalveolar lavage fluid (BAL), we obtained BAL from 30 smokers twice, the first before smoking (after 8 h of abstinence) and the second 2 min to 1 h
Vinu S Siva et al.
Fish & shellfish immunology, 59, 1-8 (2016-11-05)
Serine protease inhibitors (SPIs) play a crucial role in regulation of both host and bacterial serine protease. They are classified into several protein families, where Kazal-type inhibitors are one of families with multi-domain. In the present study, the polymorphism of
William R Swindell et al.
International journal of molecular sciences, 22(16) (2021-08-28)
Tetrahexyldecyl Ascorbate (THDC) is an L-ascorbic acid precursor with improved stability and ability to penetrate the epidermis. The stability and transdermal penetration of THDC, however, may be compromised by the oxidant-rich environment of human skin. In this study, we show
Transgenic chickpea expressing a recombinant human a1-proteinase inhibitor (a1-PI) driven by a seed-specific promoters from the common bean Phaseolus vulgaris (L.).
Mishra, S., Jha, S., Singh, R., Chaudhary, S., Sanyal, I., & Amla, D. V.
Plant Cell, Tissue and Organ Culture, 115, 23-33 (2013)
M Rouis et al.
Arteriosclerosis (Dallas, Tex.), 10(2), 246-255 (1990-03-01)
We investigated the effects of a number of stimulatory agents on the production of both cell-associated and extracellular elastase-type enzymes on human monocyte-macrophages in vitro and of the modulation of such effects by modification of cellular cholesterol content. The stimulatory
View All Related Papers

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Enzymatic Assay of Elastase (EC 3.4.21.36)

Enzymatic Assay of Elastase (EC 3.4.21.36), a continuous spectrophotometric rate determination.

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