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Merck
CN

S4813

Anti-α1-Syntrophin (RA-16) antibody produced in rabbit

buffered aqueous solution, IgG fraction of antiserum

Synonym(s):

Anti-SNTA1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD03454688
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry (frozen sections)
microarray
western blot
Species reactivity:
rat
Citations:
8
Technique(s):
immunohistochemistry (frozen sections): suitable using 0.5% paraformaldehyde fixed/0.5% Triton X-100 treated rat skeletal muscle
microarray: suitable
western blot: 1:2,000 using rat skeletal muscle homogenate extract (membrane fraction)

Key Documents

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Product Name

Anti-α1-Syntrophin (RA-16) antibody produced in rabbit, buffered aqueous solution, IgG fraction of antiserum

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 60 kDa

species reactivity

rat

technique(s)

immunohistochemistry (frozen sections): suitable using 0.5% paraformaldehyde fixed/0.5% Triton X-100 treated rat skeletal muscle
microarray: suitable
western blot: 1:2,000 using rat skeletal muscle homogenate extract (membrane fraction)

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

mouse ... Snta1(20648)
rat ... Snta1(362242)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

α1-syntrophin (SNTA1) is a dystrophin-associated protein, that has four domains- a postsynaptic density protein-95/disc large/zona occludens-1 (PDZ) domain, two pleckstrin homology (PH1 and PH2) domains and a syntrophin unique (SU) domain. It is located on human chromosome 20q11.2. It is usually present in the peripheral cytoplasmic membrane.
Anti-α1-Syntrophin (RA-16) is developed in rabbit using a synthetic peptide corresponding to a sequence of mouse α1-syntrophin The syntrophins are a family of intracellular peripheral membrane proteins (58-60 kDa), comprising at least three isoforms α1, β1, and β2-syntrophins. Syntrophins in mammalian skeletal muscle have been shown to be part of a complex of proteins associated with dystrophin, the product of Duchenne/Becker muscular dystrophy gene. The C-terminal 57 amino acids region of syntrophins is highly conserved among the three isoforms, and may contain the binding site for dystrophin.

Application

Anti-α1-Syntrophin (RA-16) antibody produced in rabbit has been used in immunohistochemistry and immunoblotting.

Biochem/physiol Actions

α1-Syntrophin recruit signaling proteins(2) to the membrane via association with the dystrophin complex.
α1-syntrophin (SNTA1) mutations results in LQTS (cardiac channelopathies like long QT syndrome). It modulates the development of adipocyte lipid droplet. It also participates in the survival signaling pathway in myoblasts. α1-syntrophin controls voltage-gated Na+ channels. It acts as a substrate for stress-activated protein kinase-3 (SAPK-3).

Immunogen

synthetic peptide corresponding to a sequence of mouse α1-syntrophin (amino acids 191-206 with N-terminally added lysine) conjugated to KLH.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
088M4840V
088M4840V
061K4885

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The adaptor protein alpha-syntrophin regulates adipocyte lipid droplet growth
Eisinger K, et al.
Experimental Cell Research, 345(1), 100-107 (2016)
?-Syntrophin is involved in the survival signaling pathway in myoblasts under menadione-induced oxidative stress
Lim JA, et al.
Experimental Cell Research, 344(1), 1-10 (2016)
gamma1-and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells
Piluso G, et al.
Test, 275(21), 15851-15860 (2000)
Dystrophin 71 and alpha1syntrophin in morpho-functional plasticity of rat supraoptic nuclei: Effect of saline surcharge and reversibly normal hydration
Sifi M, et al.
Acta Histochemica, 120(3), 187-195 (2018)
Clinical utility gene card for: long-QT syndrome (types 1-13)
Beckmann BM, et al.
European Journal of Human Genetics, 21(10) (2013)
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