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S5261

Sodium selenite

Name: Sodium selenite
Brand: SIGMA

BioReagent, suitable for cell culture, ≥98%

Synonym(s):

Selenious acid, Sodium salt

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About This Item

Linear Formula:

Na₂SeO₃

CAS Number:

10102-18-8

Molecular Weight:

172.94

NACRES:

NA.75

PubChem Substance ID:

24899643

UNSPSC Code:

12352205

EC Number:

233-267-9

MDL number:

MFCD00003489

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biological source

synthetic (inorganic)

Quality Level

200

product line

BioReagent

assay

≥98%

form

powder

technique(s)

cell culture | mammalian: suitable

mp

>350 °C (lit.)

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

SMILES string

[Na+].[Na+].[O-][Se]([O-])=O

InChI

1S/2Na.H2O3Se/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2

InChI key

BVTBRVFYZUCAKH-UHFFFAOYSA-L

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Related Categories

Cell Culture & Analysis

Lab Chemicals

Molecular Biology & Functional Genomics

Salts

Supplements for Cell Culture

Application

This product is cell culture tested (0.005 mg/L) and is appropriate for use in cell culture applications.

Sodium selenite is commonly used as a source of selenium in biological research, where selenium is an essential trace element that is normally provided by serum. Selenium is present in selenoproteins such as glutathione peroxidase and thioredoxin reductase, which contain the selenium analog of cysteine, selenocysteine. In particular, glutathione peroxidase has a role in detoxification in vivo as a scavenger of peroxides. Sodium selenite has been utilized in studies of cell proliferation and cancer research. It has been used to alter gene expression in HepG2 cells as analyzed by cDNA microarrays. Sodium selenite can inhibit zinc finger protein/DNA interactions. Sodium selenite has been shown to alter mitochondrial membrane potentials and thus potentially contribute to apoptosis.

pictograms

GHS06,GHS09

signalword

Danger

hcodes

H300 + H330,H315,H317,H319,H411

pcodes

P260 - P273 - P280 - P302 + P352 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

supp_hazards

EUH031

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

危险化学品

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Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha

Kia A, et al.

Glia, 66(5), 1016-1033 (2018)

Canonical TGF-beta signaling negatively regulates neuronal morphogenesis through TGIF/Smad complex-mediated CRMP2 suppression

Nakashima H, et al.

The Journal of Neuroscience, 2423-2417 (2018)

Universal cardiac induction of human pluripotent stem cells in two and three-dimensional formats: implications for in vitro maturation.

Miao Zhang et al.

Stem cells (Dayton, Ohio), 33(5), 1456-1469 (2015-02-03)

Directed cardiac differentiation of human pluripotent stem cells (hPSCs) enables disease modeling, investigation of human cardiogenesis, as well as large-scale production of cardiomyocytes (CMs) for translational purposes. Multiple CM differentiation protocols have been developed to individually address specific requirements of

Deep-sea water containing selenium provides intestinal protection against duodenal ulcers through the upregulation of Bcl-2 and thioredoxin reductase 1.

Chih-Ching Yang et al.

PloS one, 9(7), e96006-e96006 (2014-07-02)

Deep-sea water (DSW), which is rich in micronutrients and minerals and with antioxidant and anti-inflammatory qualities, may be developed as marine drugs to provide intestinal protection against duodenal ulcers. We determined several characteristics in the modified DSW. We explored duodenal

Microbiological selenate to selenite conversion for selenium removal.

Simon P W Hageman et al.

Water research, 47(7), 2118-2128 (2013-03-15)

Removal of the toxic selenium compounds selenite and selenate from waste water before discharge is becoming increasingly imperative in industrialized countries. Bacteria can reduce selenate to selenite, but also further to elemental selenium, selenide or organic selenium. In this paper

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Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

膳食抗氧化剂

抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。

Global Trade Item Number

SKU	GTIN
S5261-25G	04061835569403
S5261-10G	04061835569397
S5261-100G	04061835569380

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