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S5521

Suxibuzone

Synonym(s):

4-Butyl-4-(hydroxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione hydrogen succinate (ester)

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About This Item

Empirical Formula (Hill Notation):
C24H26N2O6
CAS Number:
27470-51-5
Molecular Weight:
438.47
UNSPSC Code:
12352202
PubChem Substance ID:
24899658
EC Number:
248-477-6
MDL number:
MFCD00079562
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form

solid

SMILES string

CCCCC1(COC(=O)CCC(O)=O)C(=O)N(N(C1=O)c2ccccc2)c3ccccc3

InChI

1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28)

InChI key

ONWXNHPOAGOMTG-UHFFFAOYSA-N

Biochem/physiol Actions

A prodrug of phenylbutazone.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
089F0243

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[The biological fate of 4-butyl-4-(beta-carboxypropionyloxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione(suxibuzone), antiinflammatory drug. I. Plasma levels and urinary excretion after oral administration of suxibuzone (author's transl)].
T Shindo et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 99(12), 1186-1200 (1979-12-01)
[The biological fate of 4-butyl-4-(beta-carboxypropionyloxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione (suxibuzone), antiinflammatory drug. II. The biological fate of suxibuzone (SB) after daily oral administration (author's transl)].
K Taira et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 100(3), 272-279 (1980-03-01)
S Yanagi et al.
Cancer letters, 36(1), 11-18 (1987-07-01)
Among phenylbutazone (PZ) and its related compounds, suxibuzone (SUX) caused the most extensive decrease in pyruvate kinase (PK) activity with lower toxicity. Therefore, we studied the effect of SUX on rat hepatocarcinogenesis to confirm our assumption that an agent which
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