S5826
SYUIQ-5
≥98% (HPLC)
Synonym(s):
N′-(10H-Indolo [3,2-b]quinolin-11-yl)-N, N-dimethyl-propane-1,3-diamine
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About This Item
Empirical Formula (Hill Notation):
C20H22N4
CAS Number:
Molecular Weight:
318.42
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: ≥20 mg/mL
storage temp.
2-8°C
SMILES string
CN(C)CCCNc1c2ccccc2nc3c4ccccc4[nH]c13
InChI
1S/C20H22N4/c1-24(2)13-7-12-21-18-14-8-3-5-10-16(14)22-19-15-9-4-6-11-17(15)23-20(18)19/h3-6,8-11,23H,7,12-13H2,1-2H3,(H,21,22)
InChI key
CTDCVGDSVHUYMA-UHFFFAOYSA-N
Application
SYUIQ-5 may be used in autophagy and DNA damage-inducing cell signaling studies.
Biochem/physiol Actions
SYUIQ-5 is a Cryptolepine derivative, which induces and stabilizes G-quadruplexes. In CNE2 and HeLa cancer cells SYUIQ-5 triggers rapid and potent telomere DNA damage through TRF2 delocalization from telomeres and induces cell death by autophagy. In low concentration the compound caused senescence and telomere shortening. It is a potent cytotoxic agent.
G-quadruplex stabilizer; induces authophagy in cancer cells.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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