S6317
L -Sulforaphane
≥95% (HPLC), Nrf/Keap activator, oil
Synonym(s):
(R)-1-Isothiocyanato-4-(methylsulfinyl)butane, 4-Methylsulfinylbutyl isothiocyanate
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About This Item
Empirical Formula (Hill Notation):
C6H11NOS2
CAS Number:
Molecular Weight:
177.29
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
oil
Product Name
Quality Segment
assay
≥95% (HPLC)
form
oil
optical activity
[α]/D -70 to -90°, c = 1.0 in chloroform-d
color
light yellow
solubility
DMSO: >5 mg/mL
storage temp.
−20°C
SMILES string
CS(=O)CCCCN=C=S
InChI
1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3/t10-/m1/s1
InChI key
SUVMJBTUFCVSAD-SNVBAGLBSA-N
Application
L-Sulforaphane was used to study Nrf2-mediated signaling in mouse primary preadipocytes6 and murine macrophage RAW 264.7 cell line.7
Biochem/physiol Actions
L-Sulforaphane is a potent, selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.
Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables.3,4 It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.3,5
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
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