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S6324

Monoclonal Anti-SNX6 antibody produced in mouse

Name: Monoclonal Anti-SNX6 antibody produced in mouse
Brand: SIGMA

clone SNX6-76, ascites fluid, buffered aqueous solution

Synonym(s):

Anti-MSTP010, Anti-Sorting Nexin 6, Anti-TFAF2, Anti-Tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

SNX6-76, monoclonal

Application:

ELISA (i), WB

Citations:

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

SNX6-76, monoclonal

form

buffered aqueous solution

mol wt

antigen ~47 kDa

species reactivity

mouse, human, bovine, rat

packaging

antibody small pack of 25 μL

technique(s)

indirect ELISA: suitable, western blot: 1:2,500-1:5,000 using total extracts of A549 cells

isotype

IgA

UniProt accession no.

Q9UNH7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SNX6(58533)
mouse ... Snx6(72183)
rat ... Snx6(362738)

Description

General description

Monoclonal Anti-SNX6 (mouse IgA isotype) is derived from the hybridoma SNX6-76 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice.

SNX6 (sorting nexin 6) is a BACE1 (Β-site APP cleaving enzyme-1)-associated protein and a constituent of retromer. It belongs to the sorting nexin (SNX) family that has a PX (Phox homology) domain at its amino terminus and a BAR (Bin/amphiphysin/Rvc) domain at its carboxyl region. It is located on chromosome 14q13.

Application

Monoclonal Anti-SNX6 antibody produced in mouse has been used in immunoblotting and ELISA.

Biochem/physiol Actions

SNX6 (sorting nexin 6) helps in retrograde trafficking of the cation-independent mannose-6-phosphate receptor (CI-MPR) and sortilin. Interaction of SNX6 with breast cancer metastasis suppressor-1 induces transcriptional repression. It helps in the synthesis of lamin A and its transportation to the nuclear envelope .

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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