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Merck
CN

S6324

Monoclonal Anti-SNX6 antibody produced in mouse

clone SNX6-76, ascites fluid, buffered aqueous solution

Synonym(s):

Anti-MSTP010, Anti-Sorting Nexin 6, Anti-TFAF2, Anti-Tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

SNX6-76, monoclonal

form

buffered aqueous solution

mol wt

antigen ~47 kDa

species reactivity

mouse, human, bovine, rat

packaging

antibody small pack of 25 μL

technique(s)

indirect ELISA: suitable
western blot: 1:2,500-1:5,000 using total extracts of A549 cells

isotype

IgA

UniProt accession no.

Q9UNH7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SNX6(58533)
mouse ... Snx6(72183)
rat ... Snx6(362738)

Related Categories

General description

Monoclonal Anti-SNX6 (mouse IgA isotype) is derived from the hybridoma SNX6-76 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice.
SNX6 (sorting nexin 6) is a BACE1 (Β-site APP cleaving enzyme-1)-associated protein and a constituent of retromer. It belongs to the sorting nexin (SNX) family that has a PX (Phox homology) domain at its amino terminus and a BAR (Bin/amphiphysin/Rvc) domain at its carboxyl region. It is located on chromosome 14q13.

Application

Monoclonal Anti-SNX6 antibody produced in mouse has been used in immunoblotting and ELISA.

Biochem/physiol Actions

SNX6 (sorting nexin 6) helps in retrograde trafficking of the cation-independent mannose-6-phosphate receptor (CI-MPR) and sortilin. Interaction of SNX6 with breast cancer metastasis suppressor-1 induces transcriptional repression. It helps in the synthesis of lamin A and its transportation to the nuclear envelope .

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
118K4778

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Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope
Gonzalez-Granado JM, et al.
PLoS ONE, 9(12) (2014)
Ana Jimenez-Orgaz et al.
The EMBO journal, 37(2), 235-254 (2017-11-22)
Retromer is an endosomal multi-protein complex that organizes the endocytic recycling of a vast range of integral membrane proteins. Here, we establish an additional retromer function in controlling the activity and localization of the late endosomal small GTPase RAB7. Surprisingly
Akshay Bareja et al.
The Journal of biological chemistry, 293(17), 6449-6459 (2018-03-14)
The insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase with critical roles in various biological processes. Recent results from clinical trials targeting IGF1R indicate that IGF1R signaling pathways are more complex than previously thought. Moreover, it has
Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes
Kamnasaran D, et al.
Genomics, 85(5), 608-621 (2005)
Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing
Okada H, et al.
Faseb Journal, 24(8), 2783-2794 (2010)
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Related Content

Data Sheet - S6324

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