S6883
Substance P acetate salt hydrate
≥95% (HPLC), NK-1 agonist, powder
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About This Item
Product Name
Substance P acetate salt hydrate, ≥95% (HPLC), powder
Quality Segment
assay
≥95% (HPLC)
form
powder
mol wt
1348 Da by calculation (Average Mass)
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white
solubility
0.1 M acetic acid: 1 mg/mL
UniProt accession no.
storage temp.
−20°C
SMILES string
[H]O[H].CC(O)=O.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O
InChI
1S/C63H98N18O13S.C2H4O2.H2O/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;1-2(3)4;/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);1H3,(H,3,4);1H2/t40-,41-,42-,43-,44-,45-,46?,47-,48-,49-;;/m0../s1
InChI key
VHKFRLDSEZYWAC-CIYRQLMPSA-N
Gene Information
human ... TAC1(6863)
General description
Substance P is a member of the tachykinin family of peptides. It is encoded by the tachykinin precursor 1 (TAC1) gene mapped to human chromosome 7q21-q22. Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.
Application
- used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in mice
- administered in central nucleus (ACE) in rat to study its positive reinforcing effects
- used in competition binding assays
- used as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat
Biochem/physiol Actions
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| S6883-5MG | 04061836959678 |
| S6883-1.3MG-KC | 04061832677866 |
| S6883-25MG | 04061832677880 |
| S6883-.5MG | 04061832677859 |
| S6883-10MG | 04061836959661 |
| S6883-1MG | 04061826153277 |