S7010
Span® 60
Synonym(s):
Sorbitan stearate, Sorbitane monostearate
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About This Item
CAS Number:
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12161900
EC Number:
215-664-9
MDL number:
InChI key
HVUMOYIDDBPOLL-XGKPLOKHSA-N
InChI
1S/C24H46O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h20-21,23-26,28H,2-19H2,1H3/t20-,21?,23+,24+/m0/s1
SMILES string
CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O
description
non-ionic
mol wt
430.63 g/mol
concentration
45-55% (GC)
Quality Level
Related Categories
Application
Span® 60 has been used in a study to assess encapsulation of doxorubicin in niosomes as a route to tumor targeting. It has also been used in a study to investigate the use of nonionic surfactants as contrast agents for use in diagnostic ultrasounds.
General description
Span® 60 is a sorbitan monoester than is used as a non-ionic detergent.
Other Notes
Fatty acid composition: Stearic acid (C18:0) approx. 50%; balance primarily palmitic acid (C16:0).
Legal Information
Span is a registered trademark of Croda International PLC
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Preparation and properties of vesicles (niosomes) of sorbitan monoesters ([TM="Span"] 20, 40, 60 and 80) and a sorbitan triester ([TM="Span"] 85).
Yoshioka, T., et al.
International Journal of Pharmaceutics, 105, 1-1 (1994)
I F Uchegbu et al.
Pharmaceutical research, 12(7), 1019-1024 (1995-07-01)
Encapsulation of doxorubicin in niosomes was sought as a route to tumour targeting and improved tumoricidal through the alteration of doxorubicin pharmacokinetics and metabolism. Doxorubicin niosomes (10 mg kg-1 doxorubicin) prepared from sorbitan monostearate (Span 60), cholesterol and choleth-24 (a
Surfactant-stabilized microbubbles as ultrasound contrast agents: stability study of [TM="Span"] 60 and Tween 80 mixtures using a Langmuir trough
Singhal, S., et al.
Langmuir, 9, 2426-2426 (1993)
Isabel F Almeida et al.
International journal of pharmaceutics, 327(1-2), 73-77 (2006-09-26)
Oleogels are semisolid systems obtained with an organogelator and a hydrophobic liquid that have been investigated over the past few years and that could play an important role as dermatological bases. Recently, we have developed an oleogel of sorbitan monostearate
Yvette Meissner et al.
International journal of pharmaceutics, 335(1-2), 147-153 (2006-12-08)
Low molecular weight heparins (LMWH) have shown efficacy in the treatment of inflammatory bowel disease after parenteral administration however risking severe hemorrhagic adverse effects. Therefore, an oral colonic targeted heparin dosage form allowing the release of LMWH directly in the
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