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S7826

SMER3

≥98% (HPLC)

Synonym(s):

9H-Indeno-[1,2-e]-[1,2,5]-oxadiazolo-[3,4-b]-pyrazin-9-one

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About This Item

Empirical Formula (Hill Notation):
C11H4N4O2
CAS Number:
67200-34-4
Molecular Weight:
224.18
NACRES:
NA.77
PubChem Substance ID:
329824591
UNSPSC Code:
12352200
MDL number:
MFCD00451458
Assay:
≥98% (HPLC)
Form:
powder
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assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: ≥30 mg/mL

storage temp.

2-8°C

SMILES string

O=C1c2ccccc2-c3nc4nonc4nc13

InChI

1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H

InChI key

SFSSAKVWCKFRHE-UHFFFAOYSA-N

Application

SMER3 may be used in cell signaling studies.

Biochem/physiol Actions

Inhibition of SCFMet30 by SMER3 blocks the ubiquitination of Met4 and activates the Met4-containing transcription complex. The induction of MET-genes results in cell cycle arrest and reduced cell proliferation.1
Small molecule enhancer of rapamycin (SMER); specific inhibitor of Ubiquitin E3 ligase.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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