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S7900

Saponin from quillaja bark

Name: Saponin from quillaja bark
Brand: SIGMA

Sapogenin content ≥10 %

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About This Item

CAS Number:

8047-15-2

UNSPSC Code:

12161902

EC Number:

232-462-6

NACRES:

NA.32

MDL number:

MFCD00081981

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description

non-ionic

Quality Level

200

composition

Sapogenin content, ≥10%

technique(s)

HPLC: suitable, protein quantification: suitable

sulfated ash

<20%

SMILES string

O1[C@H]([C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O)O[C@H]2[C@@H](O[C@@H]([C@H]([C@@H]2O)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)CO)C(=O)O)O[C@@H]3[C@@](C4[C@@](C5[C@]([C@@]6(C[C@H]([C@]7([C@H]([C@@H](C(CC7C6=CC5)(C)C)OC(=O)\C(=C/C)\C)OC(=O)C)CO)O)C)(CC4)C)(CC3)C

InChI key

AXNVHPCVMSNXNP-ZELRDNAQSA-N

Related Categories

Biochemicals

Detergents - Anionic, Cationic, Zwitterionic, Anti-foaming

General description

Saponins are natural steroidal glycoside (terpenes).

Application

Saponin from Quillaja bark has been used:

to stain CD4⁺ and CD8⁺ T-cells
to lyse trophozoite-infected red blood cells
in immunohistochemical staining

Biochem/physiol Actions

Saponins solubilize the low density lipoprotein (LDL) fraction of cholesterol in micelles, thus lowering their concentration. Saponin from Quillaja bark is used as a flavoring agent in food and beverages. This saponin has been shown to enhance immune-cell proliferation in vitro.

Saponins are associated with many biological and pharmacological activities. It is known to stimulate immune response in mammals. Hence it is used as vaccine adjuvants. Saponins possesses antiviral, antifungal, antitumor, anti-inflammatory, hypoglycemic and hypocholesterolemic effects.

Potent hemolytic when injected i.v.; surfactant that enhances penetration of proteins and other macromolecules through cell membranes; it also has been used as an adjuvant for vaccines.

pictograms

GHS07

signalword

Warning

hcodes

H319,H335

pcodes

P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells.

Samantha Reiss et al.

PloS one, 12(10), e0186998-e0186998 (2017-10-25)

The identification and study of antigen-specific CD4 T cells, both in peripheral blood and in tissues, is key for a broad range of immunological research, including vaccine responses and infectious diseases. Detection of these cells is hampered by both their

Microbubble suspension as a carrier of oxygen and acclimated bacteria for phenanthrene biodegradation.

Joo Young Park et al.

Journal of hazardous materials, 163(2-3), 761-767 (2008-08-12)

The applicability of microbubble suspension made of saponin as a biodegradation-enhancing carrier where oxygen and pollutant-degraders are limited was studied. The saponin-microbubble suspension was used to deliver phenanthrene-degrading bacteria, inorganic nutrients, and oxygen. Bench-scale study was carried out to determine

Induction of human papillomavirus-specific CD4(+) and CD8(+) lymphocytes by E7-pulsed autologous dendritic cells in patients with human papillomavirus type 16- and 18-positive cervical cancer.

Santin AD

Journal of Virology, 73(7), 5402-5410 (1999)

Metabolite profiling of the intraerythrocytic malaria parasite Plasmodium falciparum by (1)H NMR spectroscopy.

Teng R

Nmr in Biomedicine, 22(3), 292-302 (2009)

Acid extrusion from the intraerythrocytic malaria parasite is not via a Na(+)/H(+) exchanger.

Natalie J Spillman et al.

Molecular and biochemical parasitology, 162(1), 96-99 (2008-08-05)

The intraerythrocytic malaria parasite, Plasmodium falciparum maintains an intracellular pH (pH(i)) of around 7.3. If subjected to an experimentally imposed acidification the parasite extrudes H(+), thereby undergoing a pH(i) recovery. In a recent study, Bennett et al. [Bennett TN, Patel

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Global Trade Item Number

SKU	GTIN
S7900-25G	04061835559145
S7900-100G	04061835559138

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