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S8502

(−)-Scopolamine methyl bromide

Name: (&#8722;)-Scopolamine methyl bromide
Brand: SIGMA

≥98% (HPLC), mAChRs antagonist, powder

Synonym(s):

Hyoscine methyl bromide, Methscopolamine bromide

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₄NO₄ · Br

CAS Number:

155-41-9

Molecular Weight:

398.29

NACRES:

NA.77

PubChem Substance ID:

24278714

UNSPSC Code:

12352116

EC Number:

205-844-5

MDL number:

MFCD00078560

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

(−)-Scopolamine methyl bromide, ≥98% (HPLC), powder

Quality Segment

200

assay

≥98% (HPLC)

form

powder

optical activity

[α]25/D −25°, c = 5 in H₂O(lit.)

color

white

solubility

H₂O: 50 mg/mL

SMILES string

[Br-].[H][C@]12C[C@@H](C[C@]([H])([C@@]3([H])O[C@@]13[H])[N+]2(C)C)OC(=O)[C@H](CO)c4ccccc4

InChI

1S/C18H24NO4.BrH/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11;/h3-7,12-17,20H,8-10H2,1-2H3;1H/q+1;/p-1/t12-,13-,14-,15+,16-,17+;/m1./s1

InChI key

CXYRUNPLKGGUJF-RAFJPFSSSA-M

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Description

Application

(−)-Scopolamine methyl bromide was administered to rats to inhibit the peripheral cholinergic effects induced by pilocarpine.^10,11

Biochem/physiol Actions

Competitive muscarinic acetylcholine receptor antagonist.

Scopolamine is an anti-muscarinic and cholinolytic alkaloid that inhibits parasympathetic-cholinergic system.⁷ The central effects include hallucinations, disorientation, restlessness and euphoria.⁸ Scopolamine disturb the stimulus detection performance in rats by interfering with the reticular cholinergic pathways.⁹

Disclaimer

Shelf-life of the powder is at least five years when stored at room temperature.

pictograms

GHS07,GHS09

signalword

Warning

hcodes

H312 + H332,H400

pcodes

P261 - P271 - P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c