S8567
SU 4312
≥98% (HPLC)
Synonym(s):
3-(4-Dimethylaminobenzylidenyl)-2-indolinone, 3-[[(4-Dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture
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About This Item
Empirical Formula (Hill Notation):
C17H16N2O
CAS Number:
Molecular Weight:
264.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
orange
solubility
DMSO: >10 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
CN(C)c1ccc(cc1)\C=C2\C(=O)Nc3ccccc23
InChI
1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11+
InChI key
UAKWLVYMKBWHMX-RVDMUPIBSA-N
Gene Information
human ... FLT1(2321)
Application
SU 4312 was used to study angiogenesis during development of zebrafish embryos.2
Biochem/physiol Actions
SU 4312 inhibits the neuronal NOS and exhibits neuroprotection against NO-mediated neurotoxicity. It might be effective in treatment of neurodegenerative disorders.1
SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Other Notes
This product is a mixture of the cis- and trans- isomers. The ratio is about 55:45 based on HPLC.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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