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S8689

Fas Ligand, soluble human

Name: Fas Ligand, soluble human
Brand: SIGMA

recombinant, expressed in HEK 293 cells, lyophilized powder

Synonym(s):

SuperFas Ligand^™

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.56

MDL number:

MFCD01092558

Form:

lyophilized powder

Assay:

≥95% (SDS-GE)

Biological source:

human

Recombinant:

expressed in HEK 293 cells

Mol wt:

32 kDa by SDS-PAGE (nonglycosylated form, under reducing conditions), 35 kDa by SDS-PAGE (glycosylated form, under reducing conditions)

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biological source

human

Quality Level

200

recombinant

expressed in HEK 293 cells

assay

≥95% (SDS-GE)

form

lyophilized powder

mol wt

32 kDa by SDS-PAGE (nonglycosylated form, under reducing conditions), 35 kDa by SDS-PAGE (glycosylated form, under reducing conditions)

technique(s)

ligand binding assay: suitable

UniProt accession no.

P48023

storage temp.

−20°C

Gene Information

human ... FASLG(356)

Application

ED₅₀ = 1 ng/ml on A20 cells. Does not require any enhancer, as the modified linker sequence already facilitates the formation of active FasL complexes. rhsSuperFas Ligand^™ recognizes its receptor Fas (CD95) of the following species: human, rat, mouse.

Biochem/physiol Actions

Fas ligand has also been shown to be involved in the activation of non-apoptotic pathways including proliferation and NF-κ B activation.

Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).

Legal Information

SuperFas Ligand is a trademark of Alexis Biochemicals Corp.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Non-apoptotic Fas signaling.

Harald Wajant et al.

Cytokine & growth factor reviews, 14(1), 53-66 (2002-12-18)

Fas (Apo-1, CD95) and Fas-Ligand (FasL, CD95L) are typical members of the TNF receptor and TNF ligand family, respectively, with a pivotal role in the regulation of apoptotic processes, including activation-induced cell death, T-cell-induced cytotoxicity, immune privilege and tumor surveillance.

Global Trade Item Number

SKU	GTIN
S8689-5UG	04061838072108

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