Strychnine hydrochloride

Name: Strychnine hydrochloride
Brand: SIGMA

glycine receptor antagonist

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₂N₂O₂ · HCl

CAS Number:

1421-86-9

Molecular Weight:

370.87

NACRES:

NA.32

PubChem Substance ID:

24899812

UNSPSC Code:

12352210

EC Number:

215-826-9

MDL number:

MFCD00058174

Quality level:

100

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Properties

Product Name

Strychnine hydrochloride,

Quality Level

100

SMILES string

Cl.[H][C@@]12CC(=O)N3c4ccccc4[C@]56CCN7CC(=CCO1)[C@]([H])(C[C@@]57[H])[C@]2([H])[C@]36[H]

InChI

1S/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19-,20-,21+;/m0./s1

InChI key

VLXYTKMPCOQKEM-ZEYGOCRCSA-N

Description

Application

Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions. It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions.

Biochem/physiol Actions

Strychnine is a potent convulsant, which is extracted from Strychnos nux vomica seeds. At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.

Convulsant; glycine receptor antagonist not associated with the NMDA receptor.