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S8817

SB 218795

>98% (HPLC)

Synonym(s):

(−)-(R)-N-(α-Methoxycarbonylbenzyl)-2-phenylquinoline-4-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C25H20N2O3
Molecular Weight:
396.44
UNSPSC Code:
12352200
PubChem Substance ID:
24278467
MDL number:
MFCD00951240
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Quality Segment

assay

>98% (HPLC)

form

solid

color

white

solubility

DMSO: soluble 40 mg/mL, H2O: insoluble

storage temp.

2-8°C

SMILES string

COC(=O)[C@H](NC(=O)c1cc(nc2ccccc12)-c3ccccc3)c4ccccc4

Gene Information

Application

The pharmacodynamics profile of SB 218795 enables its use as a tool to study physiological and pathophysiological roles of NK-3 receptor in CNS-modulated behaviors.

Biochem/physiol Actions

Non-peptide NK3 tachykinin receptor antagonist.
SB 218795 is a 2-phenyl-4-quinolinecarboxamides and a selective, reversible and competitive antagonist of human NK-3 receptor that effectively crosses the blood-brain barrier. It inhibits the NK-3 receptor-induced miosis or pupil constriction in conscious rabbits.1,2

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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