S8817
SB 218795
>98% (HPLC)
Synonym(s):
(−)-(R)-N-(α-Methoxycarbonylbenzyl)-2-phenylquinoline-4-carboxamide
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C25H20N2O3
Molecular Weight:
396.44
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Quality Segment
assay
>98% (HPLC)
form
solid
color
white
solubility
DMSO: soluble 40 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
COC(=O)[C@H](NC(=O)c1cc(nc2ccccc12)-c3ccccc3)c4ccccc4
Gene Information
human ... TACR2(6865), TACR3(6870)
Application
The pharmacodynamics profile of SB 218795 enables its use as a tool to study physiological and pathophysiological roles of NK-3 receptor in CNS-modulated behaviors.
Biochem/physiol Actions
Non-peptide NK3 tachykinin receptor antagonist.
SB 218795 is a 2-phenyl-4-quinolinecarboxamides and a selective, reversible and competitive antagonist of human NK-3 receptor that effectively crosses the blood-brain barrier. It inhibits the NK-3 receptor-induced miosis or pupil constriction in conscious rabbits.1,2
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.