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Merck
CN

S9192

Ser-Leu-Ile-Gly-Lys-Val-amide

≥95% (HPLC), Proteinase-activated receptor-2 (PAR2) activator, solid

Synonym(s):

PAR-2 (1-6) Human, PAR2 activating peptide, PAR2-AP, SLIGKV-NH2

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About This Item

Empirical Formula (Hill Notation):
C28H54N8O7
CAS Number:
190383-13-2
Molecular Weight:
614.78
UNSPSC Code:
12352200
PubChem Substance ID:
329824618
NACRES:
NA.32
MDL number:
MFCD02259590

Key Documents

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Product Name

Ser-Leu-Ile-Gly-Lys-Val-amide, ≥95% (HPLC), solid

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O

InChI key

HOWDUIVVWDUEED-WAUHAFJUSA-N

InChI

1S/C28H54N8O7/c1-7-17(6)23(36-27(42)20(12-15(2)3)34-25(40)18(30)14-37)28(43)32-13-21(38)33-19(10-8-9-11-29)26(41)35-22(16(4)5)24(31)39/h15-20,22-23,37H,7-14,29-30H2,1-6H3,(H2,31,39)(H,32,43)(H,33,38)(H,34,40)(H,35,41)(H,36,42)/t17-,18-,19-,20-,22-,23-/m0/s1

assay

≥95% (HPLC)

form

solid

UniProt accession no.

Q9WTL4

storage temp.

−20°C

Quality Level

200

Gene Information

mouse ... Insrr(23920)

Related Categories

Biochem/physiol Actions

Proteinase-activated receptor (PAR-2) is a member of proteolytically cleaved receptors. It is activated by a synthetic peptide (SLIGKV), that is exposed after trypsin cleavage of the amino terminus. PAR-2 stimulates an increase in cytosolic Ca2+ ion concentration.
Proteinase-activated receptor-2 (PAR2)-activating peptide.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
0000348607
0000348607
0000226590
0000226590
0000095939

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Kenjiro Kaji et al.
Veterinary pathology, 58(1), 53-62 (2020-10-16)
Protease-activated receptor-2 (PAR2) is a G protein-coupled receptor that is activated by serine proteases. In humans, PAR2 is highly expressed in various cancers, including breast cancer, and is associated with cancer progression and metastasis. However, the expression and roles of
Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2
BoHM SK, et al.
The Biochemical Journal, 314(3), 1009-1016 (1996)
Induction of vascular smooth muscle cell growth by selective activation of the proteinase activated receptor-2 (PAR-2)
Bono F, et al.
Biochemical and Biophysical Research Communications, 241(3), 762-764 (1997)
D Quanjun et al.
European review for medical and pharmacological sciences, 20(22), 4688-4696 (2016-12-03)
Esophageal Cancer (EC) is a common malignant tumor occurred in the digestive tract. In this study, we investigated the mechanism of Protease Activated Receptor 2 (PAR-2) on the proliferation of esophageal cancer cell. Transfected esophageal cancer (EC) cell (PAR-2shRNA EC109)
Hendrik Ungefroren et al.
Molecular pharmacology, 92(5), 519-532 (2017-08-27)
Transforming growth factor-
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