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S9192

Ser-Leu-Ile-Gly-Lys-Val-amide

Name: Ser-Leu-Ile-Gly-Lys-Val-amide
Brand: SIGMA

≥95% (HPLC), Proteinase-activated receptor-2 (PAR2) activator, solid

Synonym(s):

PAR-2 (1-6) Human, PAR2 activating peptide, PAR2-AP, SLIGKV-NH2

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₅₄N₈O₇

CAS Number:

190383-13-2

Molecular Weight:

614.78

UNSPSC Code:

12352200

PubChem Substance ID:

329824618

NACRES:

NA.32

MDL number:

MFCD02259590

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Product Name

Ser-Leu-Ile-Gly-Lys-Val-amide, ≥95% (HPLC), solid

Quality Level

200

assay

≥95% (HPLC)

form

solid

UniProt accession no.

Q9WTL4

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O

InChI

1S/C28H54N8O7/c1-7-17(6)23(36-27(42)20(12-15(2)3)34-25(40)18(30)14-37)28(43)32-13-21(38)33-19(10-8-9-11-29)26(41)35-22(16(4)5)24(31)39/h15-20,22-23,37H,7-14,29-30H2,1-6H3,(H2,31,39)(H,32,43)(H,33,38)(H,34,40)(H,35,41)(H,36,42)/t17-,18-,19-,20-,22-,23-/m0/s1

InChI key

HOWDUIVVWDUEED-WAUHAFJUSA-N

Gene Information

mouse ... Insrr(23920)

Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

Proteinase-activated receptor (PAR-2) is a member of proteolytically cleaved receptors. It is activated by a synthetic peptide (SLIGKV), that is exposed after trypsin cleavage of the amino terminus. PAR-2 stimulates an increase in cytosolic Ca²⁺ ion concentration.

Proteinase-activated receptor-2 (PAR2)-activating peptide.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

0000348607

0000226590

0000095939

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Protease-Activated Receptor-2 Is Associated With Adverse Outcomes in Canine Mammary Carcinoma.

Kenjiro Kaji et al.

Veterinary pathology, 58(1), 53-62 (2020-10-16)

Protease-activated receptor-2 (PAR2) is a G protein-coupled receptor that is activated by serine proteases. In humans, PAR2 is highly expressed in various cancers, including breast cancer, and is associated with cancer progression and metastasis. However, the expression and roles of

Transforming Growth Factor-

Hendrik Ungefroren et al.

Molecular pharmacology, 92(5), 519-532 (2017-08-27)

Transforming growth factor-

Effect and mechanism of PAR-2 on the proliferation of esophageal cancer cells.

D Quanjun et al.

European review for medical and pharmacological sciences, 20(22), 4688-4696 (2016-12-03)

Esophageal Cancer (EC) is a common malignant tumor occurred in the digestive tract. In this study, we investigated the mechanism of Protease Activated Receptor 2 (PAR-2) on the proliferation of esophageal cancer cell. Transfected esophageal cancer (EC) cell (PAR-2shRNA EC109)

The Protease Activated Receptor2 Promotes Rab5a Mediated Generation of Pro-metastatic Microvesicles.

Kaushik Das et al.

Scientific reports, 8(1), 7357-7357 (2018-05-11)

Metastasis, the hallmark of cancer propagation is attributed by the modification of phenotypic/functional behavior of cells to break attachment and migrate to distant body parts. Cancer cell-secreted microvesicles (MVs) contribute immensely in disease propagation. These nano-vesicles, generated from plasma membrane

Induction of Vascular Smooth Muscle Cell Growth by Selective Activation of the Proteinase Activated Receptor-2 (PAR-2)

F. Bono

Biochemical and Biophysical Research Communications (1997)

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Global Trade Item Number

SKU	GTIN
S9192-1MG	04061836961268

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