S9311
SIB 1893
>99%, solid
Synonym(s):
[E]-2-Methyl-6-[2-phenylethenyl]pyridine
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About This Item
Empirical Formula (Hill Notation):
C14H13N
CAS Number:
Molecular Weight:
195.26
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
>99%
Form:
solid
Quality Segment
assay
>99%
form
solid
solubility
DMSO: 18 mg/mL
storage temp.
2-8°C
SMILES string
Cc1cccc(\C=C\c2ccccc2)n1
InChI
1S/C14H13N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-11H,1H3/b11-10+
InChI key
SISOFUCTXZKSOQ-ZHACJKMWSA-N
Gene Information
human ... GRM1(2911), GRM5(2915)
Application
SIB 1893 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies.
Biochem/physiol Actions
SIB 1893 non-competitively inhibits glutamate-induced increase in Ca2+ at human metabotropic glutamate receptor 1 (hmGluR1).1 It also acts as a positive allosteric modulator of hmGluR4.2
Selective and noncompetitive mGlu5 metabotropic glutamate receptor antagonist.
Features and Benefits
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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