S9446
Sphingosine Kinase 1 human
aqueous glycerol solution
Synonym(s):
SPHK 1
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About This Item
Specific activity:
≥10 units/μg
Recombinant:
expressed in baculovirus infected insect cells
recombinant
expressed in baculovirus infected insect cells
Quality Segment
form
solution
specific activity
≥10 units/μg
mol wt
47 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... SPHK1(8877)
General description
Sphingosine 1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis.
Application
Sphingosine kinase 1 has been used in a study to assess the modulation of cellular S1P levels. Sphingosine kinase 1 has also been used in a study to investigate how FTY720 normalizes hyperglycemia.
Biochem/physiol Actions
Converts sphingosine to sphingosine-1-phosphate. SPHK1 shares two large conserved regions with SPHK2. While SPHK1 is found only in the cytosol, SPHK2 is localized in both the cytosol and nuclei.
Physical form
Supplied in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween 20, 50% glycerol, 3 mM DTT.
aqueous glycerol solution
Other Notes
One unit will produce 1.0 pmole of sphingosine-1-phosphate from ATP and D-erythro-sphingosine per minute at pH 7.4, 37 °C.
wgk
WGK 1
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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