S9549
Superoxide dismutase–polyethylene glycol from bovine erythrocytes
lyophilized powder, ≥1,350 units/mg protein
Synonym(s):
PEG-SOD
Product Name
Superoxide dismutase–polyethylene glycol from bovine erythrocytes, lyophilized powder, ≥1,350 units/mg protein
form
lyophilized powder
specific activity
≥1,350 units/mg protein
mol wt
5000 Da
composition
Protein, ≥20% biuret
extent of labeling
≥10 mol PEG per mol protein
storage temp.
−20°C
Application
Superoxide dismutase-polyethylene glycol from bovine erythrocytes has been used:
- in the incubation of lung slices for measurement of dihydroethidium (DHE) fluorescence in cultured bovine pulmonary artery endothelial cells
- as supplement in T cell culture to investigate its effect on cytokine production
- in the preincubation of the carotid artery sections prior to DHE treatment
Biochem/physiol Actions
Superoxide dismutase-polyethylene glycol (SOD-PEG) is effective than SOD in scavenging free radicals in injuries. It reduces oxidative damage in ovarian follicles cell culture and during ovarian tissue transplantation. SOD-PEG is also effective in scavenging superoxide in mitochondrial abnormalities.
General description
Superoxide dismutase from bovine erythrocytes is a copper and zinc superoxide dismutase. Copper and zinc ions are coordinated by active site histidine residues. It has β-barrel structure.
Other Notes
Superoxide dismutase from bovine erythrocytes coupled to methoxy-polyethylene glycol, M.W. 5,000, through secondary amine linkage.
Packaging
Package size based on protein content
Physical form
Lyophilized powder containing PEG plus 5% citrate buffer salts
Preparation Note
Enzyme derived
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
低风险生物材料
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Polyethylene glycol-superoxide dismutase prevents endotoxin-induced cardiac dysfunction
Supinski GS and Callahan LA
American Journal of Respiratory and Critical Care Medicine, 173(11), 1240-1247 (2006)
Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity.
Yi X, Yuan D, Farr SA, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 191, 34-46 (2014)
Role of increased guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation
Chen W, et al.
The Journal of Biological Chemistry, 286, 13846-13851 (2011)
Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia
Dayal S, et al.
PLoS ONE, 12(4), e0175732-e0175732 (2017)
The beneficial effects of polyethylene glycol-superoxide dismutase on ovarian tissue culture and transplantation
Kim EJ, et al.
Journal of Assisted Reproduction and Genetics, 32(10), 1561-1569 (2015)
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