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Merck
CN

S9761

N-Succinyl-Ala-Ala-Pro-Phe-7-amido-4-methylcoumarin

leucine aminopeptidase substrate, ≥98% (HPLC), powder

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About This Item

Empirical Formula (Hill Notation):
C34H39N5O9
CAS Number:
88467-45-2
Molecular Weight:
661.70
UNSPSC Code:
12352204
PubChem Substance ID:
24899855
NACRES:
NA.32
MDL number:
MFCD00080246

Key Documents

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Product Name

N-Succinyl-Ala-Ala-Pro-Phe-7-amido-4-methylcoumarin, Leucine aminopeptidase substrate

SMILES string

CC(NC(=O)CCC(O)=O)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(Cc2ccccc2)C(=O)Nc3ccc4C(C)=CC(=O)Oc4c3

InChI

1S/C34H39N5O9/c1-19-16-30(43)48-27-18-23(11-12-24(19)27)37-32(45)25(17-22-8-5-4-6-9-22)38-33(46)26-10-7-15-39(26)34(47)21(3)36-31(44)20(2)35-28(40)13-14-29(41)42/h4-6,8-9,11-12,16,18,20-21,25-26H,7,10,13-15,17H2,1-3H3,(H,35,40)(H,36,44)(H,37,45)(H,38,46)(H,41,42)

InChI key

FMVUZZZUYBXQGR-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

solubility

methanol: 50 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

200

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCCB4105
BCBR8112V
BCBK3103V
BCBF6954V
1394976

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Activity of cathepsin H,B and metalloproteinase in the serum of patients with acute myocardial infarction.
A László et al.
Clinica chimica acta; international journal of clinical chemistry, 210(3), 233-235 (1992-09-30)
Julián Gamboa-Delgado et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 158(4), 251-258 (2010-12-21)
The effect of diet on larval growth, anionic trypsinogen gene expression (ssetryp1), and trypsin (EC 3.4.21.4) and chymotrypsin (EC 3.4.21.1) activities was assessed in Solea senegalensis. Changes in larval carbon stable isotope (δ(13)C) composition were used to estimate carbon assimilation.
I Sohár et al.
Acta biologica Hungarica, 42(1-3), 265-274 (1991-01-01)
Previously, MMP-7ases were isolated from rat skeletal muscle by gel filtration and anion exchange chromatography. The enzyme that hydrolyzed succinyl-Ala-Ala-Pro-Phe-AMC (AMC: 7-amino-4-methyl-coumarin) was inhibited by EDTA. In this study we attempted to isolate MMP-7ase from mouse kidney. The isolation procedure
G B Irvine et al.
Analytical biochemistry, 185(2), 304-307 (1990-03-01)
A simple, inexpensive, and sensitive assay for peptidase activity has been devised. The assay was performed in a microtiter plate and was based on fluorogenic peptide substrates, many of which are commercially available. 7-Amino-4-methyl coumarin the fluorescent product liberated during
Brittany Butts et al.
Frontiers in cardiovascular medicine, 10, 1132786-1132786 (2023-06-02)
Chymase is a highly destructive serine protease rapidly neutralized in the circulation by protease inhibitors. Here we test whether pericardial fluid (PCF) chymase activation and other inflammatory biomarkers determine intensive care unit length of stay, and explore mechanisms of chymase
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