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Key Documents

SAB1300134

Sigma-Aldrich

Monoclonal Anti-SET07 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-H4-K20-HMTase, Anti-Histone H4-K20 methyltransferase, Anti-PR/SET07, PR/SET domain-containing protein 07, SET domain-containing protein 8

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

43AT890, monoclonal

form

buffered aqueous solution

species reactivity

human, mouse

technique(s)

indirect ELISA: 1:1000
western blot: 1:100-1:500

isotype

IgG1

NCBI accession no.

AAF97812

UniProt accession no.

Q9NQR1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SET07(387893)

Related Categories

General description

SET07 is a histone methyltransferase that methylates Lys-20 of histone H4. H4 Lys-20 methylation represents a specific tag for epigenetic transcriptional repression. The nuclear SET07 protein, which associates with silent chromatin on euchromatic arms but shows no association with constitutive heterochromatin, prefers nucleosomes as substrate compared to free histones. It appears that SET07 may play a role in maintaining silent chromatin by preventing neighboring acetylation of H4 tail. Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity.

Immunogen

SET07 (AAF97812, N Terminal)
This antibody was raised using purified recombinant GST fusion protein encoding N-terminal of human SET07.

Physical form

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
010M1775

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