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SAB1300686

Anti-CYP26A1 (center) antibody produced in rabbit

saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution

Synonym(s):

Anti-CYP26A1, Cytochrome P450, family 26, subfamily A, polypeptide 1 (Cytochrome P450, family 26, subfamily A, polypeptide 1, isoform CRA_b)

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-CYP26A1 (center) antibody produced in rabbit, saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

saturated ammonium sulfate (SAS) precipitated

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: 1:1000
western blot: 1:100-1:500

NCBI accession no.

NP_000774

UniProt accession no.

O43174

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CYP26A1(1592)

Biochem/physiol Actions

Cytochrome P450 family 26 subfamily A member 1 (CYP26A1) is a retinoic acid (RA) degrading enzyme. It plays a vital role in RA metabolism. CYP26A1 has an essential role in the correct anteroposterior patterning and the generation of migratory cranial neural crest cells in the developing mammalian brain. Mutations in the gene is associated with the pathogenesis of optic nerve aplasia (ONA).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Cytochrome P450 family 26 subfamily A member 1 (CYP26A1) is encoded by the gene mapped to human chromosome 10q23.33.

The previously assigned protein identifier Q5VXI0 has been merged into O43174. Full details can be found on the UniProt database.

Immunogen

CYP26A1 (NP_000774, 123-157)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human CYP26A1.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
020M1728

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Nonsyndromic bilateral and unilateral optic nerve aplasia: first familial occurrence and potential implication of CYP26A1 and CYP26C1 genes.
Meire F
Molecular Vision, 17, 2072-2079 (2011)
Biochemical Basis for Dominant Inheritance, Variable Penetrance, and Maternal Effects in RBP4 Congenital Eye Disease.
Chou CM
Cell, 161, 634-646 (2015)

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