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Merck
CN

SAB1300711

Anti-MSH3 (center) antibody produced in rabbit

saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution

Synonym(s):

Anti-DNA mismatch repair protein Msh3, Anti-DUP, Anti-Divergent upstream protein, Anti-MRP1, Mismatch repair protein 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

saturated ammonium sulfate (SAS) precipitated

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: 1:1000
western blot: 1:100-1:500

NCBI accession no.

NP_002430

UniProt accession no.

P20585

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MSH3(4437)

General description

MSH3 is a component of the post-replicative DNA mismatch repair system (MMR). THis protein heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, it forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Immunogen

MSH3 (NP_002430, 464-497)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human MSH3.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
020M1751

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