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Merck
CN

SAB1309022

Anti-phospho-mouse TSC1(S561) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Hamartin, Tuberous sclerosis 1 protein homolog, Tsc1, Kiaa0243

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About This Item

UNSPSC Code:
12352203

Key Documents

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biological source

(Mouse)

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

form

liquid

mol wt

128746Da

species reactivity

mouse

technique(s)

dot blot: 1:500

isotype

IgG

NCBI accession no.

NP_075025.2

storage temp.

-10 to -25°C

target post-translational modification

phosphorylation (pSer561), phosphorylation (pSer561)

Gene Information

mouse ... Tsc1(64930)

General description

In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

Biochem/physiol Actions

This mouse TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S561 of mouse TSC1.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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