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SAB1402233

Monoclonal Anti-HSPA4 antibody produced in mouse

Name: Monoclonal Anti-HSPA4 antibody produced in mouse
Brand: SIGMA

clone 3A11, purified immunoglobulin, buffered aqueous solution

Synonym(s):

APG-2, HS24/P52, MGC131852, RY, hsp70, hsp70RY

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

3A11, monoclonal

Application:

ELISA (i), WB

Citations:

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Properties

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3A11, monoclonal

form

buffered aqueous solution

mol wt

antigen ~42.39 kDa

species reactivity

human

technique(s)

indirect ELISA: suitable, western blot: 1-5 μg/mL

isotype

IgG2aκ

NCBI accession no.

BC002526

UniProt accession no.

P34932

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HSPA4(3308)

Description

Immunogen

HSPA4 (AAH02526, 1 a.a. ~ 148 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNAKNTVQGFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEEQNGPVDGQGDNPGPQAAEQGTDTAVPSDSDKKLPEMDID

Biochem/physiol Actions

Hspa4 (heat shock protein family A (Hsp70) member 4) is an important ATP-dependent cytosolic chaperone along with Hsp90. Hspa4 aids in the folding of several proteins and helps in protecting against cellular stresses such as rise in temperature. Hspa4 maintains the function of the mitotic centrosome to coordinates bipolar mitotic spindle assembly. Hspa4 might compensate the loss of parkin function in mice by protecting the cells against proteolytic and mitochondrial stress. Therefore, it can serve as an important therapeutic agent for parkinson disease. Upregulation of HSPA4 is observed in parkin gene knockout mice. Hspa4 is known to be associated with tumor progression and offers resistance against many therapeutic agents. The gene is upregulated in many different types of cancer.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number

08225-3A11

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HSP70 regulates the function of mitotic centrosomes.

Fang CT

Cellular and Molecular Life Sciences, 73(20), 3949-3960 (2016)

Heat Shock Proteins Promote Cancer: It's a Protection Racket.

Calderwood SK and Gong J

Trends in Biochemical Sciences, 41(4), 311-323 (2016)

Induction of Hsp70 in tumor cells treated with inhibitors of the Hsp90 activity: A predictive marker and promising target for radiosensitization.

Kudryavtsev VA, et.al.

PLoS ONE, 12(3), 1-25 (2017)

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Global Trade Item Number

SKU	GTIN
SAB1402233-100UG	04061829608309