SAB1403470
Monoclonal Anti-BNIPL, (N-terminal) antibody produced in mouse
clone 2C8, purified immunoglobulin, buffered aqueous solution
Synonym(s):
BNIP-S, BNIPL-1, BNIPL-2, BNIPL1, BNIPL2, PP753
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
2C8, monoclonal
Application:
ELISA (i), WB
Citations:
3
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
2C8, monoclonal
form
buffered aqueous solution
mol wt
antigen ~56.36 kDa
species reactivity
human
technique(s)
indirect ELISA: suitable, western blot: 1-5 μg/mL
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BNIPL(149428)
General description
The gene BNIPL (Bcl-2/adenovirus E1B 19kDa interacting protein 2-like) encodes a protein containing BNIP-2 and Cdc42GAP homology (BCH) domain and has a molar mass of 19kDa. It is abundantly expressed in human placenta and lung.
Immunogen
BNIPL (AAH27868, 1 a.a. ~ 275 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MRKRLSAPELRLSLTKGPGNDGASPTQSAPSSPDGSSDLEIDELETPSDSEQLDSGHEFEWEDELPRAEGLGTSETAERLGRGCMWDVTGEDGHHWRVFRMGPREQRVDMTVIEPYKKVLSHGGYHGDGLNAVILFASCYLPRSSIPNYTYVMEHLFRYMVGTLELLVAENYLLVHLSGGTSRAQVPPLSWIRQCYRTLDRRLRKNLRALVVVHATWYVKAFLALLRPFISSKFTRKIRFLDSLGELAQLISLDQVHIPEAVRQLDRDLHGSGGT
Sequence
MRKRLSAPELRLSLTKGPGNDGASPTQSAPSSPDGSSDLEIDELETPSDSEQLDSGHEFEWEDELPRAEGLGTSETAERLGRGCMWDVTGEDGHHWRVFRMGPREQRVDMTVIEPYKKVLSHGGYHGDGLNAVILFASCYLPRSSIPNYTYVMEHLFRYMVGTLELLVAENYLLVHLSGGTSRAQVPPLSWIRQCYRTLDRRLRKNLRALVVVHATWYVKAFLALLRPFISSKFTRKIRFLDSLGELAQLISLDQVHIPEAVRQLDRDLHGSGGT
Biochem/physiol Actions
The gene BNIPL (Bcl-2/adenovirus E1B 19 kDa interacting protein 2-like) encodes a protein of the BNIPL family that functions in the apoptotic pathway. The BCH (BNIP-2 and Cdc42GAP homology) domain plays a crucial role by interacting with Bcl-2 and Cdc42GAP and inducing cell death. It serves as a linker protein in Bcl-2 pathway for DNA fragmentation. It also participates in Cdc42 (cell division control) signaling for changes in cell morphology and membrane blebbing during apoptosis. It facilitates invasion and cancer metastasis.
Physical form
Solution in phosphate buffered saline, pH 7.4
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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