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Merck
CN

SAB1403609

Monoclonal Anti-BMP2, (C-terminal) antibody produced in mouse

clone 4B12, purified immunoglobulin, buffered aqueous solution

Synonym(s):

BMP2A

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Monoclonal Anti-BMP2, (C-terminal) antibody produced in mouse, clone 4B12, purified immunoglobulin, buffered aqueous solution

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4B12, monoclonal

form

buffered aqueous solution

mol wt

antigen ~38.65 kDa

species reactivity

human

technique(s)

indirect ELISA: suitable
proximity ligation assay: suitable

isotype

IgG2aκ

NCBI accession no.

NM_001200

UniProt accession no.

P12643

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... BMP2(650)

Biochem/physiol Actions

Bone morphogenetic proteins (BMPs) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. During bone repair, BMP2 controls the expression of Runt-related transcription factor 2 (Runx2) and osterix (Osx), thereby enhancing migration, proliferation and osteogenic differentiation of mesenchymal stem cells. In addition to its osteogenic activity, BMP2 also plays an important role in cardiac morphogenesis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Bone morphogenetic protein 2 (BMP2) belongs to the transforming growth factor-β (TGF-β) superfamily. It is expressed in a variety of tissues such as heart, lung and dorsal aorta. The gene encoding this protein is localized on human chromosome 20p12.3.

Immunogen

BMP2 (NP_001191, 283 a.a. ~ 396 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
QAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
G9231-4B12
07184-4B12

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Adenoviral Mediated Expression of BMP2 by Bone Marrow Stromal Cells Cultured in 3D Copolymer Scaffolds Enhances Bone Formation.
Sharma S
PLoS ONE (2016)
BMP and BMP inhibitors in bone.
Rosen V
Annals of the New York Academy of Sciences (2006)
Alternative Neural Crest Cell Fates Are Instructively Promoted by TGF? Superfamily Members
Nirao MShah
Cell (1996)
BMP2 is required for early heart development during a distinct time period.
Schlange T
Mechanisms of Development (2000)
Duplications Involving a Conserved Regulatory Element Downstream of BMP2 Are Associated with Brachydactyly Type A2
KatarinaDathe
Academic Journal of Interdisciplinary Studies (2009)

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