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SAB1405214

Sigma-Aldrich

Monoclonal Anti-XPO5 antibody produced in mouse

clone 2C5-1B3, ascites fluid

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Synonym(s):
FLJ14239, FLJ32057, FLJ45606, KIAA1291
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

2C5-1B3, monoclonal

mol wt

antigen ~56.91 kDa

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: 1:500-1:1000

isotype

IgG1κ

NCBI accession no.

BC000129

UniProt accession no.

Q9HAV4

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... XPO5(57510)

General description

Exportin-5 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments.[supplied by OMIM

Immunogen

XPO5 (AAH00129, 1 a.a. ~ 280 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MRLSQKWQVINQRSLLCGEDEAADENPESQEMLEEQLVRMLTREVMDLITVCCVSKKGADHSSAPPADGDDEEMMATEVTPSAMAELTDLGKCLMKHEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLSGTLLADAVTWLFTSVLKGLQMHGQHDGCMASLVHLAFQIYEALRPRYLEIRAVMEQIPEIQKDSLDQFDCKLLNPSLQKVADKRRKDQFKRLIAGCIGKPLGEQFRKEVHIKNLPSLFKKTKPMLETEVLDNDGGGLATIFEP

Biochem/physiol Actions

XPO5 (exportin 5) is responsible for the translocation of miRNA (micro-RNA) precursor from nucleus to cytoplasm. Studies in HeLa cells show that miR-138 lowers the stability of XPO5 protein, thus, decreasing miRNA processing. This protein is also involved in the transport of short hairpin (shRNA). It docks on the nuclear pore complex and transports three classes of RNAs, tRNA, Y-RNA and miRNA precursors, across the nuclear membrane, in a RanGTP-RanGDP gradient-dependent manner.

Physical form

Clear solution

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Jie Li et al.
Nucleic acids research, 42(1), 458-474 (2013-09-24)
MicroRNAs (miRNAs) are a class of non-coding small RNAs that consist of ≈ 22 nt and are involved in several biological processes by regulating target gene expression. MiR-138 has many biological functions and is often downregulated in cancers. Our results
Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs.
Yi R et al
RNA, 11(2), 220-226 (2005)
Yamina Bennasser et al.
Nature structural & molecular biology, 18(3), 323-327 (2011-02-08)
MicroRNAs (miRNAs) are a class of small, noncoding RNAs that function by regulating gene expression post-transcriptionally. Alterations in miRNA expression can strongly influence cellular physiology. Here we demonstrated cross-regulation between two components of the RNA interference (RNAi) machinery in human

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