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SAB1405214

Sigma-Aldrich

Monoclonal Anti-XPO5 antibody produced in mouse

clone 2C5-1B3, ascites fluid

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别名:
FLJ14239, FLJ32057, FLJ45606, KIAA1291
NACRES:
NA.41

生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

ascites fluid

antibody product type

primary antibodies

克隆

2C5-1B3, monoclonal

分子量

antigen ~56.91 kDa

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: 1:500-1:1000

同位素/亚型

IgG1κ

NCBI登记号

UniProt登记号

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... XPO5(57510)

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此商品
HPA018402WH0064398M1SAB5201860
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

ascites fluid

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

clone

2C5-1B3, monoclonal

clone

polyclonal

clone

1D12, monoclonal

clone

12F7, monoclonal

mol wt

antigen ~56.91 kDa

mol wt

-

mol wt

-

mol wt

58kDa

species reactivity

human

species reactivity

human, rat, mouse

species reactivity

human

species reactivity

human

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一般描述

Exportin-5 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments.[supplied by OMIM

免疫原

XPO5 (AAH00129, 1 a.a. ~ 280 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MRLSQKWQVINQRSLLCGEDEAADENPESQEMLEEQLVRMLTREVMDLITVCCVSKKGADHSSAPPADGDDEEMMATEVTPSAMAELTDLGKCLMKHEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLSGTLLADAVTWLFTSVLKGLQMHGQHDGCMASLVHLAFQIYEALRPRYLEIRAVMEQIPEIQKDSLDQFDCKLLNPSLQKVADKRRKDQFKRLIAGCIGKPLGEQFRKEVHIKNLPSLFKKTKPMLETEVLDNDGGGLATIFEP

生化/生理作用

XPO5 (exportin 5) is responsible for the translocation of miRNA (micro-RNA) precursor from nucleus to cytoplasm. Studies in HeLa cells show that miR-138 lowers the stability of XPO5 protein, thus, decreasing miRNA processing. This protein is also involved in the transport of short hairpin (shRNA). It docks on the nuclear pore complex and transports three classes of RNAs, tRNA, Y-RNA and miRNA precursors, across the nuclear membrane, in a RanGTP-RanGDP gradient-dependent manner.

外形

Clear solution

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Jie Li et al.
Nucleic acids research, 42(1), 458-474 (2013-09-24)
MicroRNAs (miRNAs) are a class of non-coding small RNAs that consist of ≈ 22 nt and are involved in several biological processes by regulating target gene expression. MiR-138 has many biological functions and is often downregulated in cancers. Our results
Yamina Bennasser et al.
Nature structural & molecular biology, 18(3), 323-327 (2011-02-08)
MicroRNAs (miRNAs) are a class of small, noncoding RNAs that function by regulating gene expression post-transcriptionally. Alterations in miRNA expression can strongly influence cellular physiology. Here we demonstrated cross-regulation between two components of the RNA interference (RNAi) machinery in human
Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs.
Yi R et al
RNA, 11(2), 220-226 (2005)

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