SAB1407352
Anti-VENTX antibody produced in mouse
purified immunoglobulin, buffered aqueous solution
Synonym(s):
HPX42B, MGC119910, MGC119911, NA88A, VENTX2
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
5
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~27.6 kDa
species reactivity
human
technique(s)
indirect immunofluorescence: suitable, western blot: 1 μg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... VENTX(27287)
Related Categories
General description
This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas (provided by RefSeq). Vent homeobox (VENTX) is a human homeobox transcription factor. VENTX is majorly expressed in human myeloid cells. VENTX gene is located on human chromosome 10q26.3.
Immunogen
VENTX (NP_055283.1, 1 a.a. ~ 258 a.a) full-length human protein.
Sequence
MRLSSSPPRGPQQLSSFGSVDWLSQSSCSGPTHTPRPADFSLGSLPGPGQTSGAREPPQAVSIKEAAGSSNLPAPERTMAGLSKEPNTLRAPRVRTAFTMEQVRTLEGVFQHHQYLSPLERKRLAREMQLSEVQIKTWFQNRRMKHKRQMQDPQLHSPFSGSLHAPPAFYSTSSGLANGLQLLCPWAPLSGPQALMLPPGSFWGLCQVAQEALASAGASCCGQPLASHPPTPGRPSLGPALSTGPRGLCAMPQTGDAF
Sequence
MRLSSSPPRGPQQLSSFGSVDWLSQSSCSGPTHTPRPADFSLGSLPGPGQTSGAREPPQAVSIKEAAGSSNLPAPERTMAGLSKEPNTLRAPRVRTAFTMEQVRTLEGVFQHHQYLSPLERKRLAREMQLSEVQIKTWFQNRRMKHKRQMQDPQLHSPFSGSLHAPPAFYSTSSGLANGLQLLCPWAPLSGPQALMLPPGSFWGLCQVAQEALASAGASCCGQPLASHPPTPGRPSLGPALSTGPRGLCAMPQTGDAF
Biochem/physiol Actions
Vent homeobox(VENTX) regulates proliferation and differentiation of hematopoietic cells.VENTX acts as a tumor suppressor and plays an important role in proinflammatory activation.Dysregulation of VENTX may contribute to pathogenesis of autoimmune diseases.
Physical form
Solution in phosphate buffered saline, pH 7.4
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
Homeobox transcription factor VentX regulates differentiation and maturation of human dendritic cells
Wu X, et al.
The Journal of Biological Chemistry, M113-M113 (2014)
The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation
Wu X, et al.
The Journal of Clinical Investigation, 121(7) (2011)
Homeobox protein VentX induces p53-independent apoptosis in cancer cells
Gao H, et al.
Oncotarget, 7(26), 39719-39719 (2016)
VENTX induces expansion of primitive erythroid cells and contributes to the development of acute myeloid leukemia in mice
Gentner E, et al.
Oncotarget, 7(52), 86889-86889 (2016)
Classification and nomenclature of all human homeobox genes
Holland PWH, et al.
BMC Biology, 5(1), 47-47 (2007)
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