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Merck
CN

SAB1408140

Anti-TNS4 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Synonym(s):

CTEN, FLJ14950, PP14434

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
3
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biological source

mouse

Quality Segment

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~51.8 kDa

species reactivity

human

technique(s)

indirect immunofluorescence: suitable, western blot: 1 μg/mL

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TNS4(84951)

General description

Mouse polyclonal antibody raised against a full-length human TNS4 protein.
TNS4 (Tensin 4) is a signaling molecule localized in the prostate and placenta. It is a member of the TENSIN gene family. It has a Src homology 2 and phosphotyrosine-binding domains. Its expression has been observed in the early progression of melanoma cells.

Immunogen

TNS4 (AAH18706.1, 1 a.a. ~ 480 a.a) full-length human protein.

Sequence
MGSKASSPHGLGSPLVASPRLEKRLGGLAPQRGSRISVLSASPVSDVSYMFGSSQSLLHSSNSSHQSSSRSLESPANSSSSLHSLGSVSLCTRPSDFQAPRNPTLTMGQPRTPHSPPLAKEHASSCPPSITNSMVDIPIVLINGCPEPGSSPPQRTPGHQNSVQPGAASPSNPCPATRSNSQTLSDAPFTTCPEGPARDMQPTMKFVMDTSKYWFKPNITREQAIELLRKEEPGAFVIRDSSSYRGSFGLALKVQEVPASAQSRPGEDSNDLIRHFLIESSAKGVHLKGADEEPYFGSLSAFVCQHSIMALALPCKLTIPQRELGGADGASDSTDSPASCQKKSAGCHTLYLSSVSVETLTGALAVQKAISTTFERDILPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLTTLRFCGMDPEQRKWQKYCKPSWIFGFVAKSQTEPQENVCHLFAEYDMVQPASQVIGLVTALLQDAERM

Application

Anti-TNS4 antibody produced in mouse is suitable for indirect immunofluorescence and western blot.

Biochem/physiol Actions

TNS4 (Tensin 4) is mainly involved in cell migration activity. It exhibits oncogenic property in colonic, breast, lung, and gastric cancers. In studies, its overexpression has been reported in the pancreatic cancer cells. In pancreatic cancer cells, TNS4 promotes colony formation and cell motility. It has been predicted that TNS4 could be a prognostic marker for primary melanoma.

Physical form

Solution in phosphate buffered saline, pH 7.4


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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable



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