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SAB1412447

ANTI-HOXB7 antibody produced in mouse

clone 4C6, purified immunoglobulin, buffered aqueous solution

Synonym(s):

HHO.C1, HOX2, HOX2C, HOXB7, Hox-2.3

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
4C6, monoclonal
Application:
ELISA (i), IHC, WB
Citations:
8

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4C6, monoclonal

form

buffered aqueous solution

mol wt

antigen 33 kDa

species reactivity

human

technique(s)

immunohistochemistry: suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL

isotype

IgG1κ

NCBI accession no.

NM_004502

UniProt accession no.

P09629

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... HOXB7(3217)

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General description

Homeobox B7 (HOXB7) is part of the HOX gene family and is expressed in embryonic tissues. The gene encoding it is localized on human chromosome 17q21.32.

Immunogen

HOXB7 (NP_004493, 55 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MQGLYPGGGGMAGQSAAGVYAAGYGLEPSSFNMHCAPFEQNLSGVCPGDSAKAAGAKEQRDSDLAA

Biochem/physiol Actions

Homeobox B7 (HOXB7) has a role in many cellular processes. It has been shown to be expressed in hepatocellular carcinoma. HOXB7 may also have a role in cell migration and invasion in gastric cancer. This transcription factor is vital for tissue differentiation and embryogenesis. HOXB7 may be a potential drug target in various cancers. The protein has the capacity to induce the expression of genes associated with tumor invasion and angiogenesis.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

低风险生物材料
常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
12174-S672
11326-4C6

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Identification of several potential chromatin binding sites of HOXB7 and its downstream target genes in breast cancer.
Heinonen H
International Journal of Cancer. Journal International Du Cancer, 137, 2374-2383 (2015)
The roles of HOXB7 in promoting migration, invasion, and anti-apoptosis in gastric cancer.
Joo MK, et.al.
Journal of Gastroenterology and Hepatology, 31, 1717-1726 (2016)
HOXB7-S3 inhibits the proliferation and invasion of MCF-7 human breast cancer cells.
Ma R
Molecular Medicine Reports, 12, 4901-4908 (2015)
HOXB7 Expression is a Novel Biomarker for Long-term Prognosis After Resection of Hepatocellular Carcinoma.
Komatsu H
Anticancer Research, 36, 2767-2773 (2016)
Serologic analysis of ovarian tumor antigens reveals a bias toward antigens encoded on 17q.
Stone B
International Journal of Cancer. Journal International Du Cancer, 104, 73-84 (2003)
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