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Merck
CN

SAB2100474

Anti-CPEB4 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-Cytoplasmic polyadenylation element binding protein 4, Anti-KIAA1673

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

80 kDa

species reactivity

human, dog, mouse, guinea pig, rabbit, rat

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

UniProt accession no.

Q17RY0

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CPEB4(80315)

General description

Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) is a sequence-specific binding protein that belongs to the CPEB family. It consists of two domains, an unstructured domain, and a RNA binding domain. CPEB4 is expressed in the spinal cord and brain. The CPEB4 gene is mapped on the human chromosome at 5q35.2.

Immunogen

Synthetic peptide directed towards the N terminal region of human CPEB4

Biochem/physiol Actions

Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) plays a key role in translational control during tumor development and modulates various biological processes in tumor progression, including invasion, metastasis, tumor cell growth, and vascularization. It is involved in pathologic angiogenesis, terminal erythroid differentiation, and non-neuronal tissues for cancer progression. Overexpression of the CPEB4 gene is associated with pancreatic ductal adenocarcinoma and glioblastoma.

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Other Notes

Synthetic peptide located within the following region: DEILGSEKAKSQQQEQQDPLEKQQLSPSPGQEAGILPETEKAKSEENQGD

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
QC58858
QC10113

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Jihae Shin et al.
Scientific reports, 6, 29395-29395 (2016-07-07)
CPEB4 is an RNA binding protein expressed in neuronal tissues including brain and spinal cord. CPEB4 has two domains: one that is structured for RNA binding and one that is unstructured and low complexity that has no known function. Unstructured
Wanming Hu et al.
Medicine, 94(27), e979-e979 (2015-07-15)
CPEB4 plays an important role in cancer progression. However, the clinicopathological significance of CPEB4 expression to glioma and its expression levels in glioma tissues and cell lines are unknown. The present study investigated the potential prognostic value of CPEB4 for

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