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Merck
CN

SAB2101415

Anti-MAFB antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-KRML, Anti-MGC43127, Anti-V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD07370390
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
human, rat, guinea pig, horse, bovine, mouse, dog
Citations:
6
Technique(s):
western blot: suitable
Uniprot accession no.:
Q9Y5Q3

Key Documents

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Product Name

Anti-MAFB antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

36 kDa

species reactivity

human, rat, guinea pig, horse, bovine, mouse, dog

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

UniProt accession no.

Q9Y5Q3

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... MAFB(9935)

Biochem/physiol Actions

MAF bZIP transcription factor B (MAFB) has been implicated in the development of the hindbrain structures, thymus, interneurons, pancreatic islet cells and the hematopoietic system. In mouse, it helps in lip and palate development. MAFB regulates lineage-specific gene expression by suppressing the Ets-1-mediated transcription. The encoded protein plays an essential role in islet α-cell function. In addition, MAFB also regulates genes involved in both endocrine α- and β-cell differentiation. The protein acts as a modulator and marker of adipose tissue inflammation. Mutations in the gene is associated with the development of multicentric carpo-tarsal osteolysis (MCTO).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

MAF bZIP transcription factor B (MAFB) is encoded by the gene mapped to human chromosome 20q12. The encoded protein is a member of the maf oncogene family and is ubiquitously expressed in variety of tissues. MAFB is a 311 amino acid protein characterized with a typical basic leucine zipper (bZIP) domain in its C-terminal region.

Immunogen

Synthetic peptide directed towards the N terminal region of human MAFB

Other Notes

Synthetic peptide located within the following region: APQGSATAAEPQPGDPARASQDSADPQAPAQGNFRGSWDCSSPEGNGSPE

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
QC24403

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MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.
Artner I
Diabetes, 55, 297-304 (2006)
MAFB as a novel regulator of human adipose tissue inflammation.
Pettersson AM
Diabetologia, 58, 2115-2123 (2015)
The identification of MAFB mutations in eight patients with multicentric carpo-tarsal osteolysis supports genetic homogeneity but clinical variability.
Mehawej C
American Journal of Medical Genetics. Part A, 161A, 3023-3029 (2013)
MafB Is an Interaction Partner and Repressor of Ets-1 That Inhibits Erythroid Differentiation
Sieweke MH
Cell, 85, 49-60 (1996)
MafB, a New Maf Family Transcription Activator That Can Associate with Maf and Fos but Not with Jun
Kataoka K
Molecular and Cellular Biology, 14, 7581-7591 (1994)
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