SAB2108557
Anti-LOR
IgG fraction of antiserum
Synonym(s):
Anti-MGC111513
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Product Name
Anti-LOR, IgG fraction of antiserum
Quality Level
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
35 kDa
species reactivity
human
concentration
0.5-1 mg/mL
technique(s)
immunoblotting: suitable
immunohistochemistry: suitable
accession no.
NM_000427
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... LOR(4014)
Biochem/physiol Actions
LOR is a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel′s syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases.LOR encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in LOR may be the cause of both Vohwinkel′s syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases.
Mutations in the gene LOR, leads to an autosomal dominant genodermatosis called loricrin keratoderma. The disease is characterized by palmoplantar keratoderma and ichthyosis. Variation in the gene also results in Vohwinkel syndrome with ichthyosis and progressive symmetrical erythrokeratodermia, an inherited cornification disorder.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
The LOR gene codes for a a small basic protein, loricrin. It is predominantly localized to the cornified cell envelope.
Immunogen
Synthetic peptide directed towards the N terminal region of human LOR
Other Notes
Synthetic peptide located within the following region: GYSGGGCGGGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSG
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Novel autosomal dominant mutation in loricrin presenting as prominent ichthyosis.
Pohler E, et al.
British Journal of Dermatology, 173(5), 1291-1294 (2015)
Activation of vascular endothelial growth factor receptor 2 in a cellular model of loricrin keratoderma.
Yoneda K, et al.
The Journal of Biological Chemistry (2010)
Evidence for the absence of mutations at GJB3, GJB4 and LOR in progressive symmetrical erythrokeratodermia.
Wei S, et al.
Clinical and Experimental Dermatology, 36(4), 399-405 (2011)
Kinga Skieresz-Szewczyk et al.
Cells, 11(12) (2022-06-25)
The lingual mucosa in birds is covered with two specific types of multilayered epithelia, i.e., the para- and orthokeratinized epithelium, that differ structurally and functionally. Comprehensive information on proteins synthesized in keratinocyte during their cytodifferentiation in subsequent layers of multilayered
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