SAB2500481
Anti-GPR40 antibody produced in goat
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-G protein-coupled receptor 40, Anti-HGNC:4498
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), WB
Citations:
3
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
indirect ELISA: suitable, western blot: suitable
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GPR40(2864)
General description
G protein-coupled receptor 40 (GPR40) belongs to the G protein-coupled receptors. It is a 300 amino acid protein, that has seven characteristic transmembrane domains. GPR40 is also known as FFA1 (free fatty acid receptor 1). It is expressed in the β cell of the pancreas, spinal cord and brain. It is located on human chromosome 19q13.
Immunogen
Peptide with sequence CAARTQGGKSQK from the C Terminus of the protein sequence according to NP_005294.1.
Biochem/physiol Actions
G protein-coupled receptor 40 (GPR40) maintains insulin and glucose homeostasis. It plays an important role in the development of type 2 diabetes. GPR40/FFA1 signaling may participate in the regulation of endogenous pain control systems. It is considered as an anti-diabetic drug target.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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A single amino acid mutation (R104P) in the E/DRY motif of GPR40 impairs receptor function
Guo Shimeng, et al.
PLoS ONE, 10(10), e0141303-e0141303 (2015)
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
Briscoe Celia P, et al.
The Journal of Biological Chemistry, 278(13), 11303-11311 (2003)
A New Pain Regulatory System via the Brain Long Chain Fatty Acid Receptor GPR40/FFA1 Signal.
Nakamoto, et al.
Yakugaku Zasshi, 137(2), 199-204 (2017)
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