SAB2500814
Anti-PPP1R15A/GADD34 antibody produced in goat
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-GADD34, Anti-Growth arrest and DNA-damage-inducible 34, Anti-Protein phosphatase 1
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IHC, WB
Citations:
6
biological source
goat
Quality Segment
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PPP1R15A(23645)
General description
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) or growth arrest and DNA-damage-inducible 34 (GADD34) is the regulatory subunit of eukaryotic translation initiation factor 2 (eIF2α) phosphatase. It is expressed when there is a signal indicating endoplasmic reticulum stress. The PPP1R15A gene is localized on human chromosome 19q13.33.
Immunogen
Peptide with sequence C-AAALDLSGRRG from the C Terminus of the protein sequence according to NP_055145.2.
Biochem/physiol Actions
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) recruits and regulates the α-subunit of protein phosphatase 1 (PP1). It functions as a stress marker. When there is depletion in amino acid levels in the cell, PPP1R15A is expressed in high concentrations. It regulates the mammalian target of rapamycin (mTOR) pathway and thereby boosts autophagy in macrophages. Studies have shown that PPP1R15A is expressed in the oligodendrocytes of patients suffering from Alzheimer′s disease.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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