SAB2501722
Anti-TPO antibody produced in goat
affinity isolated antibody, buffered aqueous solution
Synonym(s):
MSA, TDH2A, TPX, thyroid peroxidase
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IHC, WB
Citations:
4
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TPO(7173)
General description
Thyroid peroxidase (TPO) is a membrane-bound, glycosylated, heme-containing peroxidase. It is encoded by the gene mapped to human chromosome 2p25.3. The encoded protein is a member of the human peroxidases family. TPO is a ~100 kDa protein with 933-amino acids. Mature TPO is characterized with a short transmembrane and cytoplasmic regions, as well as a dominant ectodomain, containing MPO-like, complement control protein (CCP)-like and epidermal growth factor (EGF)-like domains.
Immunogen
Peptide with sequence C-TRHVIQVSNEVVTDD, from the internal region of the protein sequence according toNP_000538.3; NP_783650.1; NP_783652.1; NP_783653.1
Biochem/physiol Actions
Thyroid peroxidase (TPO) is involved in the biosynthesis of thyroid hormones T3 and T4. It catalyzes the oxidation of the inorganic iodide and coupling of iodinated tyrosine to produce thyroxine and triiodothyronine. Mutation in the gene increases the risk of susceptibility to autoimmune thyroiditis in patients with allergic rhinitis and asthma. Genetic deficiency of TPO is associated with the development of congenital hypothyroidism.
Features and Benefits
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Physical form
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Serum Anti-TPO and TPO Gene Polymorphism as a Predictive Factor for Hidden Autoimmune Thyroiditis in Patient with Bronchial Asthma and Allergic Rhinitis.
El RS, et al.
The Egyptian Journal of Immunology / Egyptian Association of Immunologists, 23(1), 77-86 (2016)
Identification and characterization of VPO1, a new animal heme-containing Peroxidase
Cheng G, et al.
Free Radical Biology & Medicine, 45(12), 1682-1694 (2008)
Triallelic patterns in STR loci used for paternity analysis: Evidence for a duplication in chromosome 2 containing the TPOX STR locus
Lukka M, et al.
Forensic Science International, 164(1), 3-9 (2006)
Thyroid peroxidase (TPO) expressed in thyroid and breast tissues shows similar antigenic properties.
Godlewska M, et al.
PLoS ONE, 12(6) (2017)
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