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Merck
CN

SAB2502028

Anti-SLC6A4 (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

5-HTT, 5-HTTLPR, 5HTT, HTT, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, bovine, human, mouse

technique(s)

ELISA: suitable
flow cytometry: suitable
immunofluorescence: suitable

UniProt accession no.

P31645

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SLC6A4(6532)

Related Categories

General description

Solute carrier family 6 member 4 (SLC6A4) is also known as 5-hydroxytryptamine transporter (5-HTT). It is an integral membrane protein, which is mapped to human chromosome 17q11.2. The encoded protein is a member of the SLC6 (solute carrier family 6) gene family and is mainly expressed in brain and blood cells.

Immunogen

Peptide with sequence C-KERIIKSITPETPT, from the C-terminal region of the protein sequence according to NP_001036.1

Biochem/physiol Actions

Solute carrier family 6 member 4 (SLC6A4) catalyzes the transport of neurotransmitter serotonin from the synaptic space into presynaptic neurons. It plays a vital role in mood and anxiety regulation. Mutation in the gene may alter the expression of serotonin (5HT) in the synaptic cleft, which ultimately leads to schizophrenia. Allelic variations in the gene increase the risk of susceptibility to autism and rigid-compulsive behaviors.

Features and Benefits

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Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
1315P1
11315P1

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Linkage mapping of serotonin transporter protein gene SLC6A4 on chromosome 17
J Gelernter, et al.
Human Genetics, 95(6), 677-680 (1995)
Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets
B D Greenberg, et al.
American Journal of Medical Genetics, 88(1), 83-87 (1999)
The solute carrier 6 family of transporters
S Broer, et al.
British Journal of Pharmacology, 167(2), 256-278 (2012)
Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors
J S Sutcliffe, et al.
American Journal of Human Genetics, 77(2), 265-279 (2005)

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