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SAB2702176

Sigma-Aldrich

Monoclonal Anti-TERF1 antibody produced in mouse

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Synonym(s):
TRF, TRF1, hTRF1-AS, t-TRF1
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4E4
monoclonal

form

liquid

mol wt

70 kDa

species reactivity

human

concentration

1 mg/mL

technique(s)

immunocytochemistry: suitable
immunofluorescence: suitable

isotype

IgG1

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TERF1(7013)

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This Item
HPA048379SAB2501029SAB1406522
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

clone

4E4, monoclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

form

liquid

form

buffered aqueous glycerol solution

form

buffered aqueous solution

form

buffered aqueous solution

mol wt

70 kDa

mol wt

-

mol wt

-

mol wt

antigen ~28.3 kDa

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Immunogen

Human TRF1

Application

For ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher.

Biochem/physiol Actions

TRF1 binds the double-stranded telomeric repeat sequence, TTAGGG. TRF1 and TRF2 are key components of vertebrate telomeres and bind to double-stranded telomeric DNA as homodimers. Dimerization involves the TRF homology (TRFH) domain, which also mediates interactions with other telomeric proteins. Despite a modest sequence identity, the 2 TRFH domains have the same entirely alpha-helical architecture, resembling a twisted horseshoe. The dimerization interfaces feature unique interactions that prevent heterodimerization. Mutational analysis of TRF1 corroborated the structural data and underscored the importance of the TRFH domain in dimerization, DNA binding, and telomere localization.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Phosphate-buffered saline, no preservative added.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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