SAB2900202
Anti-CX3CR1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
beta chemokine receptor-like 1, chemokine c-x3-c receptor 1, cmkbrl1, cmkdr1, fkn receptor
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p)
Citations:
5
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CX3CR1(1524)
General description
C-X3-C motif chemokine receptor 1 (CX3CR1) is a transmembrane G-coupled chemokine receptor of its ligand, fractalkine. This receptor is expressed on epithelial cells, smooth muscle cells, microglia, monocytic cells and natural killer cells. The gene encoding CX3CR1 is localized on human chromosome 3p21.3 and has five exons.
Immunogen
Synthetic 19 amino acid peptide from 3rd extracellular domain of human CX3CR1. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Gibbon, Monkey (95%); Marmoset, Mouse, Panda (84%).
Biochem/physiol Actions
C-X3-C motif chemokine receptor 1 (CX3CR1) may be linked to the development of macular degeneration. It also acts as a receptor aiding viral entry.
Features and Benefits
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Physical form
Solution in phosphate-buffered saline containing less than 0.1% sodium azide.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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CX3CR1 polymorphisms and the risk of age-related macular degeneration.
Ma B
International Journal of Clinical and Experimental Pathology, 8(8), 9592-9596 (2015)
Fractalkine/CX3CR1 induces apoptosis resistance and proliferation through the activation of the AKT/NF-?B cascade in pancreatic cancer cells.
Wang H
Cell Biochemistry and Function, 35(6), 315-326 (2017)
CX3CR1 is an important surface molecule for respiratory syncytial virus infection in human airway epithelial cells.
Chirkova T
The Journal of General Virology, 96(9), 2543-2556 (2015)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB2900202-50UG | 04061831476941 |