SAB2900401
Anti-XAF1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
XAF 1, XAF-1, XAF1, XIAP associated factor-1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... XAF1(54739)
General description
XIAP associated factor 1 (XAF1) is a cytokine-regulated protein expressed in the cytoplasm. It contains a tumor necrosis factor receptor-associated factor (TRAF) domain. The gene encoding XAF1 is localized on human chromosome 17p13.1.
Immunogen
Synthetic peptide from human XAF1/XIAP-assoicated factor 1
Application
Anti-XAF1 antibody produced in rabbit has been used in Western blotting.
Biochem/physiol Actions
XIAP associated factor 1 (XAF1) is an inhibitor of tumor growth. It has a role in restoring X-linked inhibitor of apoptosis (XIAP)-suppressed caspase activity.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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[XAF1 inhibits cell proliferation and induces apoptosis in human lung adenocarcinoma cell line A549 in vitro].
Chen D
Zhongguo Fei ai za Zhi = Chinese Journal of Lung Cancer (2014)
X-linked inhibitor of apoptosis-associated factor 1 regulates TNF receptor 1 complex stability.
Lin B
Febs Letters (2016)
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer
Andrea Lunardi
Nature Genetics (2013)
XAF1 is frequently methylated in human esophageal cancer.
World Journal of Gastroenterology (2012)
Andrea Lunardi et al.
Nature genetics, 45(7), 747-755 (2013-06-04)
Here we report an integrated analysis that leverages data from treatment of genetic mouse models of prostate cancer along with clinical data from patients to elucidate new mechanisms of castration resistance. We show that castration counteracts tumor progression in a
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