SAB3500082
Anti-NOTUM antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-NOTUM pectinacetylesterase homolog
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, rat, mouse
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NOTUM(147111)
General description
In Drosophila, the notum gene is regulated by the Wingless pathway and encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. The mammalian homolog has been shown to be able to cleave glypicans and can release GPI-anchored proteins from the mammalian cell surface. Like the Drosophilia NOTUM, the mammalian protein can act as a negative regulator of the Wnt signaling pathway. NOTUM is expressed at a low level in most mammalian tissues, although it is overexpressed in a subset of human hepatocellular carcinomas. Its transcription is regulated by β-catenin/TCF and is a target of the Wnt signaling pathway, forming a negative feedback loop that regulates the expression and activity of the Wnt pathway.
NOTUM encodes palmitoleoyl-protein carboxylesterase. In human chromosome, the gene NOTUM is localized on 17q25.3.
Immunogen
NOTUM antibody was raised against a 19 amino acid peptide near the amino terminus of human NOTUM.
Application
Anti-NOTUM antibody produced in rabbit has been used in immunostaining.
Biochem/physiol Actions
Notum is involved in the progression of colorectal cancer and its expression levels is higher in metastatic cells. Notum is one of the pain associated genes.
Features and Benefits
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Physical form
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500082.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Establishment of a murine pancreatic cancer pain model and microarray analysis of pain-associated genes in the spinal cord dorsal horn
Wang L, et al.
Molecular Medicine Reports, 16(4), 4429-4436 (2017)
Tianyanxin Sun et al.
The Journal of clinical endocrinology and metabolism, 105(12) (2020-08-11)
Crosstalk through receptor ligand interactions at the maternal-fetal interface is impacted by fetal sex. This affects placentation in the first trimester and differences in outcomes. Sexually dimorphic signaling at early stages of placentation are not defined. Investigate the impact of
Laura Mannarino et al.
Cell death & disease, 13(7), 612-612 (2022-07-16)
Although clinical antitumor activity of Tumor Treating Fields (TTFields) has been reported in malignant pleural mesothelioma (MPM) patients, the mechanisms behind the different selectivity displayed by the various MPM histotypes to this physical therapy has not been elucidated yet. Taking
NOTUM Is Involved in the Progression of Colorectal Cancer
Yoon JH, et al.
Cancer, Genomics, and Proteomics, 15(6), 485-497 (2018)
Transcriptional dynamics of cultured human villous cytotrophoblasts
Robinson JF, et al.
Endocrinology, 158(6), 1581-1594 (2017)
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