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Merck
CN

SAB3500141

Anti-TRESK antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-KCNK18, Anti-Potassium channel subfamily K member 18, Anti-TRESK2, Anti-TRIK

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, rat, mouse

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

NP_862823

UniProt accession no.

Q7Z418

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KCNK18(338567)

General description

Potassium two pore domain channel subfamily K member 18 (KCNK18) or TRESK is part of the potassium channel family. It is expressed in trigeminal and dorsal root ganglions. The protein is activated by calcium signals. The TRESK gene is localized on human chromosome 10q25.3.

Immunogen

TRESK antibody was raised against a 17 amino acid peptide from near the center of human TRESK.

Biochem/physiol Actions

Potassium two pore domain channel subfamily K member 18 (KCNK18) or TRESK contributes to background K+ currents in sensory neurons. Mutations in the gene encoding it have been associated with familial migraine with aura.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied in PBS with 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500141.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
55571001

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TRESK: the lone ranger of two-pore domain potassium channels.
Enyedi P
Molecular and Cellular Endocrinology (2012)
Identification of novel small molecule modulators of K2P18.1 two-pore potassium channel.
Bruner JK
European Journal of Pharmacology (2014)
KCNK18 (TRESK) genetic variants in Italian patients with migraine.
Rainero I
Headache (2014)
Involvement of gap junction channels in the pathophysiology of migraine with aura
Denis Sarrouilhe
Frontiers in Physiology (2014)

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