SAB3500196
Anti-CTRP6 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-CTRP6
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), ICC, WB
Citations:
6
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse
technique(s)
immunocytochemistry: suitable, indirect ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... C1QTNF6(114904)
General description
C1q and TNF (Tumour necrosis factor) related protein 6 (CTRP6/C1QTNF6) is a glycoprotein which belongs to family of proteins containing TNF alpha-like globular domain. CTRP6 is a single peptide with a short variable region, a collagen like region, and a C-terminal globular domain. CTRP6 is expressed in human synoviocytes. In human chromosome, the gene is localized on 22q12.3.
Immunogen
CTRP6 antibody was raised against a 15 amino acid peptide from near the carboxy-terminus of human CTRP6.
Biochem/physiol Actions
C1q and TNF (Tumour necrosis factor) related protein 6 (CTRP6) plays a major role in fatty acid metabolism. CTRP6 phosphorylates AMCK (5′-AMP (adenosine monophosphate)-activated protein kinase) and ACC (acetyl coenzyme A carboxylase) and activates AMCK-ACC pathway. The expression level of CTRP6 is increased in rheumatoid arthritis. CTRP6 inhibits alternative complement pathway and helps in maintaining pregnancy. CTRP6 mediates the ectopic lipogenesis in myoblasts through AdipoR1/Erk/PPARγ (Adiponectin receptor 1/Extracellular signal-regulated kinases/Peroxisome proliferator-activated receptor gamma) signalling pathway. CTRP6 is overexpressed in hepatocellular carcinoma and stimulates angiogenesis by Akt (serine/threonine-protein kinase) pathway. CTRP6 confers susceptibility to type I diabetes. CTRP6 maybe a key regulator connecting obesity with tissue inflammation and insulin resistance.
Features and Benefits
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Physical form
Supplied in PBS with 0.02% sodium azide.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500196.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Lipogenesis in myoblasts and its regulation of CTRP6 by AdipoR1/Erk/PPAR gamma signalling pathway
Wu W, et al.
Acta biochimica et biophysica Sinica, 48(6), 509-519 (2016)
C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance
Lei X, et al.
The Journal of Biological Chemistry, 292(36), 14836-14850 (2017)
Genetic susceptibility to vitiligo: Recent progress from genome-wide association studies
Zhang Z, et al.
Dermatologica Sinica, 32(4), 225-232 (2014)
Masanori A Murayama et al.
Nature communications, 6, 8483-8483 (2015-09-26)
The complement system is important for the host defence against infection as well as for the development of inflammatory diseases. Here we show that C1q/TNF-related protein 6 (CTRP6; gene symbol C1qtnf6) expression is elevated in mouse rheumatoid arthritis (RA) models.
Expression of a secretory protein C1qTNF6, a C1qTNF family member, in hepatocellular carcinoma
Takeuchi T, et al.
Analytical Cellular Pathology, 34(3), 113-121 (2011)
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