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SAB3500318

Anti-TMEM16A antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Ano1, Anti-Anoctamin 1, Anti-Calcium activated chloride channel, Anti-DOG1, Anti-TAOS1

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
indirect ELISA
western blot
Species reactivity:
mouse, human
Citations:
3
Technique(s):
indirect ELISA: suitable
western blot: suitable
Uniprot accession no.:
Q5XXA6

Key Documents

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Product Name

Anti-TMEM16A antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human

technique(s)

indirect ELISA: suitable
western blot: suitable

NCBI accession no.

NP_060513

UniProt accession no.

Q5XXA6

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ANO1(55107)

Related Categories

Biochem/physiol Actions

Transmembrane member 16A (TMEM16A) or Ano1 is crucial for normal electrical slow waves and for the proliferation of interstitial cells of Cajal (ICC). The protein has a role in smooth muscle contraction, salivary secretion and cardiac and neuronal excitability. TMEM16A has been associated with head and neck squamous cell carcinoma and breast cancer.

Features and Benefits

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General description

Transmembrane member 16A (TMEM16A) or Anoctamin1 (Ano1) is a calcium-activated chloride channel. It is expressed in the interstitial cells of Cajal (ICC) in the gastrointestinal tract. The gene encoding this protein is localized on human chromosome 11q13.3.

Immunogen

TMEM16A antibody was raised against a 17 amino acid peptide from near the amino terminus of human TMEM16A.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500318.

Physical form

Supplied in PBS with 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
54190904

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TMEM16A/ANO1 suppression improves response to antibody-mediated targeted therapy of EGFR and HER2/ERBB2.
Kulkarni S
Genes Chromosomes Cancer (2017)
EAVK segment "c" sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1.
Strege PR
American Journal of Physiology: Gastrointestinal and Liver Physiology (2017)
GDD1 Is Identical to TMEM16E, a Member of the TMEM16 Family
Masuko K
American Journal of Human Genetics (2004)

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