SAB3500457
Anti-TEM4 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-ARHGEF17, Anti-P164RHOGEF, Anti-Rho guanine nucleotide exchange factor 17, Anti-Tumor endothelial marker 4
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC, WB
Citations:
2
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 220 kDa
species reactivity
human
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ARHGEF17(9828)
General description
Rho guanine nucleotide exchange factor 17 (ARHGEF17), also known as tumor endothelial marker 4 (TEM4) and p164-RhoGEF (Rho-specific guanine-nucleotide exchange factor), encodes a guanine nucleotide exchange factor (GEF) for RhoA GTPases. The encoded protein consists of 1510 amino acids and contains a RhoGEF-specific Dbl homology (DH) domain. It does not contain the typical pleckstrin homology domain. TEM4 is predominantly expressed in the heart. Overexpression of this protein inhibits the transcription of M3 muscarinic receptor-induced genes. TEM4 modulates endothelial cell migration.
Immunogen
TEM4 antibody was raised against a 18 amino acid peptide near the center of human TEM4.
Features and Benefits
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Physical form
Supplied in PBS with 0.02% sodium azide.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500457.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain
Ulrich Rumenapp
BioChemistry: An Indian Journal (2002)
The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility.
Mitin N
PLoS ONE (2013)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SBP3500457-0.05MG | 04061832169538 |
| SAB3500457-100UG | 04061831495447 |